Evidence map›Paper›PMID 42465918›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.

Ariadna Cilleros-Portet, Itziar González-Moro, Hachem Sadikki, Sergi Marí, Todd M Everson, Alba Hernangómez-Laderas, Lucile Broséus, Jorg Tost, Marta Cosín-Tomàs, Marika Groleau and 29 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Ariadna Cilleros-PortetDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7564-6840
Itziar González-MoroDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID 0000-0002-6504-4931
Hachem SadikkiDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6994-0557
Sergi MaríDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.
Todd M EversonGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.ORCID 0000-0003-2732-4550
Alba Hernangómez-LaderasDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID 0009-0001-9948-5399
Lucile BroséusUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France.ORCID 0000-0002-7018-2124
Jorg TostLaboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France.ORCID 0000-0002-2683-0817
Marta Cosín-TomàsISGlobal, Barcelona, Spain.ORCID 0000-0001-5012-8983
Marika GroleauDepartment of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0001-6198-7724
Darina CzamaraDepartment Genes and Environment, Max-Planck-Institute of Psychiatry, Germany.ORCID 0000-0001-7381-904X
Manuel LozanoCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID 0000-0003-2046-5959
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Johanna TuhkanenDepartment of Psychology, Faculty of Medicine, University of Helsinki, Finland.
M Daniele FallinDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.ORCID 0000-0002-9948-3908
Rebecca J SchmidtDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.ORCID 0000-0003-1582-2747
Charles E BreezeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-5294-915X
J F DeleuzeLaboratory for Functional Genomics, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France.ORCID 0000-0002-5358-4463
Sofia Aguilar-LacasañaISGlobal, Barcelona, Spain.ORCID 0000-0002-7953-1589
Pierre-Etienne JacquesDepartment of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0002-3961-294X
Soile HyttiDepartment of Psychology, Faculty of Medicine, University of Helsinki, Finland.
Amaia IrizarCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID 0000-0003-0307-3558
Marius Lahti-PulkkinenDepartment of Psychology, Faculty of Medicine, University of Helsinki, Finland.ORCID 0000-0002-5244-5525
Kelly M BakulskiDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-9605-6337
John DouDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0003-4577-8660
Jari LahtiDepartment of Psychology, Faculty of Medicine, University of Helsinki, Finland.ORCID 0000-0002-4310-5297
Martine VrijheidISGlobal, Barcelona, Spain.ORCID 0000-0002-7090-1758
Katri RäikkönenDepartment of Psychology, Faculty of Medicine, University of Helsinki, Finland.ORCID 0000-0003-3124-3470
Marie-France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0001-7752-2585
Jordi SunyerISGlobal, Barcelona, Spain.ORCID 0000-0002-2602-4110
Barbara HeudeUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Lifecourse Epidemiology, OPPaLE, F-75004 Paris, France.ORCID 0000-0002-1565-1629
Johanna LepeuleUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309. Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 GRENOBLE, France.ORCID 0000-0001-8907-197X
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.ORCID 0000-0003-4911-5290
Jia ChenDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6597-8577
Mariona BustamanteISGlobal, Barcelona, Spain.ORCID 0000-0003-0127-2860
Carmen J MarsitGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.ORCID 0000-0003-4566-150X
Jose Ramon BilbaoDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID 0000-0002-3176-501X
Corina LesseurDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6744-6750
Nora Fernandez-JimenezDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID 0000-0001-6307-0880

Funding

Integrative analysis of human placental epi/genome in relation to fetal growthR00HD097286 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LESSEUR PEREZ, CORINA · 2021 to 2023
$732k
NICHD NIH HHS R00 HD097286
6 · The paper itself

Abstract

The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that the perinatal environment shapes susceptibility to complex traits across life [1]. The placenta, a transient organ mediating maternal-fetal exchange, plays a central role in this process and has emerged as a key molecular archive

Identifiers

PMID42465918
PMCPMC13370596

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.