ArticleFrontiers in cellular and infection microbiology2026
Transcriptomic signatures differentiating carrier and dead-end fish hosts of proliferative kidney disease.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Method: Comparative transcriptomic analysis of infected kidneys from brown trout and rainbow trout was performed to identify differential gene expression patterns associated with host-specific responses to Results: A total of 636 and 1,348 unique transcripts were upregulated and downregulated in the infected kidney of brown trout, respectively. In contrast, 526 and 586 unique transcripts were upregulated and downregulated in the infected kidney of rainbow trout, respectively. The uniquely upregulated transcripts in infected brown trout were mainly associated with cell cycle and mitotic cell cycle-related processes, whereas in infected rainbow trout, they were associated with the regulation of biological quality, intracellular signal transduction, and response to chemical stimulus. Similarly, uniquely downregulated transcripts in infected brown trout were mainly associated with anatomical structure morphogenesis, cellular developmental processes, cell differentiation, animal organ development, and cell surface receptor signaling, whereas in infected rainbow trout, they were associated with transmembrane transport, ion transport, and nervous system development. Discussion: Our findings suggest that host-specific transcriptomic signatures and their differential regulation underlie the contrasting immune responses of brown trout and rainbow trout against
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