ArticleThe Pan African medical journal2026
Acute hemorrhagic edema of infancy mimicking purpura fulminans: a report of two cases.
Article in The Pan African medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis of young children characterized by cockade-like purpura and edema, usually with a preserved general condition. Because of its dramatic presentation, it may mimic life-threatening disorders such as meningococcemia with purpura fulminans, leading to extensive investigations and unnecessary treatment. We report two cases of AHEI in boys aged 18 and 22 months. The first presented with widespread purpura after a recent fever, prompting a full sepsis workup and empirical ceftriaxone before AHEI was recognized. The second had typical cockade purpura with acral edema and no fever, allowing immediate diagnosis and simple clinical monitoring. Both children recovered spontaneously, with complete resolution within 10-14 days. Early recognition of AHEI is essential to avoid misdiagnosis and to adjust management appropriately in infants presenting with purpura.
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