Evidence map›Paper›PMID 42465776›Full record

ArticleFrontiers in immunology2026

S100A8

Censhan Lin, Mingyue Wu, Ziying Zhang, Muxu Zheng, Huiqin Li, Yufang Wang, Zhanxin Du, Linxiang Wu, Junjie Dai, Yu Yu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Censhan Lin *Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Mingyue Wu *Institute of Precision Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ziying Zhang *Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Muxu Zheng *State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, China.
Huiqin LiState Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, China.
Yufang WangInstitute of Precision Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhanxin DuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Linxiang WuDepartment of Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Junjie DaiDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yu YuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xuhang DuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yehui WuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jie XuInstitute of Precision Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhongxing WangDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Fu-Li XiangInstitute of Precision Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. Although macrophage heterogeneity has been implicated in pathogenesis, the contribution of transitional macrophage states remains poorly understood. Methods: We integrated single-cell RNA-seq from 93 human lung specimens (44 IPF, 49 controls) and analyzed peripheral blood single-cell datasets (31 IPF, 17 controls). We examined differentiation trajectories and ligand-receptor networks and assessed metabolic programs. Functional relevance was evaluated in a bleomycin mouse model using histology, immunostaining, qRT-PCR, and tissue glutamine quantification. Findings: We identified an Interpretation:

Indexed as

Calgranulin ACalgranulin BIdiopathic Pulmonary FibrosisMacrophagesAnimalsBleomycinDisease Models, AnimalDisease ProgressionFemaleHumansLungMaleMiceMice, Inbred C57BLBleomycinCalgranulin ACalgranulin BS100A8 protein, humanS100A9 protein, humanEGF/AREG signalingglutamine metabolism/GLULidiopathic pulmonary fibrosismacrophage heterogeneityS100A8/S100A9transitional macrophages

Identifiers

PMID42465776
PMCPMC13372650

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.