Evidence map›Paper›PMID 42465728›Full record

ArticleFrontiers in neuroscience2026

Neurochemical-hemodynamic-electrophysiological coupling in the neonatal brain: a multimodal MRS-fMRI-EEG investigation.

Juliette L Y Champaud, Alice R Thomson, Jucha Willers Moore, Ines Tomazinho, Kathleen Colford, Vyacheslav R Karolis, Parvaneh Adibpour, Nicolaas A Puts, Lorenzo Fabrizi, Tomoki Arichi

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In one paragraph

Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliette L Y Champaud *Medawar Pain and Somatosensory Labs, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Alice R Thomson *Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Jucha Willers Moore *Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Ines TomazinhoResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Kathleen ColfordResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Vyacheslav R KarolisResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Parvaneh AdibpourResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Nicolaas A PutsMRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom.
Lorenzo FabriziMedawar Pain and Somatosensory Labs, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Tomoki ArichiResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Inhibitory and excitatory neurotransmitter levels are linked to fast neuronal oscillations and infra-slow hemodynamic fluctuations, suggesting a shared excitation-inhibition (E/I) regulatory framework across measures. However, these relationships may differ in early development, when both excitatory and inhibitory cortical systems are undergoing substantial functional and structural maturation. Consequently, we hypothesize different functional coupling between neurochemical, electrophysiological, and hemodynamic proxies of E/I signaling in healthy full-term neonates compared to what has been observed in adults. Methods: Twenty-five healthy full-term neonates (mean postmenstrual age at study = 40.1 ± 1.4 weeks) underwent multimodal MRI and electroencephalography (EEG) recordings during natural resting-state to provide proxy measures of neural excitation and inhibition. These included frontal and occipital MRS measures of Results: Occipital GABA+ was negatively correlated with beta relative power ( Discussion: Together, these preliminary findings suggest that commonly used neurochemical, oscillatory, and hemodynamic proxy measures of cortical excitatory and inhibitory processes may show only modest correspondence at birth, consistent with ongoing and hierarchal cortical development, leading to complex and asynchronous relationships between these measures.

Indexed as

ALFFbrain developmentE/I balanceFOOOFmultimodal neuroimagingneonate

Identifiers

PMID42465728
PMCPMC13372886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.