ArticleInnovation in aging2026
The association of chronic pain with suicidality in hospitalized patients with dementia: a retrospective study of the U.S. Nationwide Inpatient Sample, 2016-2020.
Article in Innovation in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objectives: Chronic pain is common in older adults and is associated with psychological distress, including suicidality. In patients with dementia, impaired cognitive and communication may further increase vulnerability. This study aimed to investigate associations between chronic pain and suicidality in hospitalized patients with dementia. Research Design and Methods: This population-based, retrospective cross-sectional study analyzed hospitalizations of patients aged ≥60 years with dementia between 2016 and 2020, extracted from the U.S. Nationwide Inpatient Sample (NIS). Chronic pain, suicide attempts, and suicidal ideations were identified using International Classification of Diseases, Tenth edition-CM diagnostic codes. Propensity score matching (1:4) was performed to balance baseline characteristics, including age, sex, race, dementia type, and major comorbidities. Multivariable logistic regression estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Stratified analyses were conducted by age, dementia type, sex, Charlson comorbidity index (CCI), race, and insurance. Results: After matching, 29,185 hospitalized patients with dementia were analyzed (5,837 with chronic pain; 23,348 without). Chronic pain was significantly associated with higher odds of suicidal ideations (adjusted odds ratio [aOR] = 1.49, 95% CI: 1.30-1.71, Discussion and Implications: Chronic pain is associated with increased suicidality in hospitalized older patients with dementia. Longitudinal studies are needed to confirm these findings.
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