ArticleFrontiers in pain research (Lausanne, Switzerland)2026
Low dose naltrexone for fibromyalgia: case series demonstrating pain relief and other health benefits.
Article in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fibromyalgia is a chronic pain disorder with multiple proposed etiologies. Pharmacological treatments approved for fibromyalgia are few and not always effective; therefore, some practitioners use off-label medications such as low dose naltrexone (LDN). This case series presents a retrospective chart review of patients who were prescribed LDN for fibromyalgia at an integrative medicine clinic over a 2-year period. Outcomes assessed included pain relief, other health benefits, side effects and prescription habits. Of 10 patients identified, LDN provided substantial pain relief for 8 patients (-4.7/10 points, average -3.75/10 for all 10 patients,
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