ArticleParkinson's disease2026
Walking Speed Explains Apparent Ground Reaction Force Differences in Parkinson's Disease: A Waveform-Level SPM Analysis During Normal and Virtual Reality Walking.
Article in Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Walking Speed Explains Apparent Ground Reaction Force Differences in Parkinson's Disease: A Waveform-Level SPM Analysis During Normal and Virtual Reality Walking.Parkinson's disease · 2026Article
- Longitudinal characterization of biomechanical alterations in a Parkinson's disease mouse model using three-dimensional ground reaction forces.Clinical parkinsonism & related disorders · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ground reaction force (GRF) alterations are reported in Parkinson's disease (PD), but most kinetic measures depend on walking speed. Since individuals with PD walk more slowly, apparent differences may reflect speed rather than disease-specific biomechanics. Virtual reality (VR) may further modify gait kinetics beyond speed effects. Objective: To determine whether between-group differences in GRF waveforms during overground walking persist after accounting for walking speed and whether VR induces speed-independent kinetic modulation in individuals with PD. Methods: 14 adults with mild-to-moderate PD (Hoehn and Yahr stage II-III) and seventeen age-matched controls performed overground walking under normal and immersive VR conditions. Three-dimensional kinematics (100 Hz) and GRFs (1000 Hz) were recorded. Discrete spatiotemporal and kinetic variables were analyzed using mixed-design repeated-measures ANOVA. Time-continuous GRF waveforms were examined using mixed-model statistical parametric mapping (SPM) ANCOVA with walking speed entered as a covariate. Results: Individuals with PD walked significantly slower than controls in both conditions. VR increased stride length and modulated several discrete GRF variables, including anterior-posterior and mediolateral components. However, waveform-level SPM analyses revealed no persistent group or group × task effects once walking speed was included as a covariate. In contrast, walking speed demonstrated widespread and robust associations with vertical and mediolateral GRF trajectories across multiple stance-phase intervals. Conclusion: During comfortable overground walking in mild-to-moderate PD, many apparent kinetic differences are largely speed-coupled rather than clearly speed-independent. These findings underscore the necessity of speed-aware modeling when interpreting gait kinetics and evaluating VR-based paradigms in Parkinson's disease.
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