Evidence map›Paper›PMID 42465499›Full record

ArticlebioRxiv : the preprint server for biology2026

A cofactor-promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis.

Isaac A Paddy, Joshua McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit Setegne, Oliv Eidam, Christine Jacobs-Wagner, Laura M K Dassama

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Isaac A PaddyDepartment of Chemical and Systems Biology, Stanford School of Medicine.
Joshua McCauslandSarafan ChEM-H Institute, Stanford University.
Madelyn FrazierSarafan ChEM-H Institute, Stanford University.
Poulami ChatterjeeSarafan ChEM-H Institute, Stanford University.
Mekedlawit SetegneSarafan ChEM-H Institute, Stanford University.
Oliv EidamInnovative Medicines Accelerator, Stanford University.
Christine Jacobs-WagnerSarafan ChEM-H Institute, Stanford University.
Laura M K DassamaSarafan ChEM-H Institute, Stanford University.

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Deciphering the molecular mechanisms of sterol lipid trafficking in bacteriaR35GM150910 · NIGMS · STANFORD UNIVERSITY · PI Laura Dassama · 2023 to 2026
$1.9M
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM150910
6 · The paper itself

Abstract

The Lyme disease pathogen

Identifiers

PMID42465499
PMCPMC13370337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.