ArticlebioRxiv : the preprint server for biology2026
Restricted MHC-II trafficking in
Avinaash K Sandhu, Daniel P Gail, Rachel C Simmermon, Demetria Webb, Laura Hmiel, Charles Bark, Bryan Bryson, Richard F Silver, Stephen Carpenter
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Avinaash K SandhuBiomedical Sciences Training Program, Department of Pathology.
Daniel P GailDivision of Infectious Diseases and HIV Medicine, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-9792-1556 Rachel C SimmermonDivision of Infectious Diseases and HIV Medicine, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Demetria WebbDivision of Infectious Diseases, Department of Medicine, Metro Health Research Institute, Cleveland, OH, USA.
Laura HmielDivision of Infectious Diseases, Department of Medicine, Metro Health Research Institute, Cleveland, OH, USA.
Charles BarkDivision of Infectious Diseases and HIV Medicine, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Bryan BrysonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-1716-6712 Richard F SilverDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Funding
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)75N93019C00071 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FORTUNE, SARAH · 2019 to 2025
$57.3MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MWG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0MEvaluating human T cells specific for Mycobacterium tuberculosis antigens that are processed and presented by infected macrophagesR01AI187662 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Stephen Matthew Carpenter · 2025 to 2026
$1.6MDetermining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine DevelopmentK08AI163407 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Stephen Matthew Carpenter · 2022 to 2026
$967kNCRR NIH HHS UL1 RR024989NIAID NIH HHS K08 AI163407NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI187662NIH HHS 75N93019C00071
6 · The paper itselfAbstract
Recognition of infected macrophages by CD4+ T cells is essential to immune protection against
Indexed as
alveolar macrophageantigen presentationCD4GM-CSFHERC5IL-10infectionM1M2M-CSFmemoryMycobacterium tuberculosisrecognitionTBT celltype I interferon
Identifiers
PMID42465483
PMCPMC13370412
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