Evidence map›Paper›PMID 42465480›Full record

ArticlebioRxiv : the preprint server for biology2026

Epithelial QKI Protects Against Emphysema by Maintaining Mitochondrial Integrity.

Kiyoshi Uemasu, Kazuya Tanimura, Atsushi Miyamoto, Koichi Hasegawa, Zachary Lane, Reika Nyunoya, Haruka Uemasu, Brett A Kaufman, Corrine R Kliment, Divay Chandra and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kiyoshi UemasuDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-5818-3028
Kazuya TanimuraDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3406-9394
Atsushi MiyamotoDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6847-9925
Koichi HasegawaMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8506-5986
Zachary LaneDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Reika NyunoyaDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Haruka UemasuDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Brett A KaufmanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-4767-4937
Corrine R KlimentDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3815-9370
Divay ChandraDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0009-0009-5555-4645
Frank SciurbaDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Charles Dela CruzDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-5258-1797
Prithu SunddVersiti Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-7568-5719
Jonathan K AlderDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3741-6512
Jian HuDepartment of Cancer Biology, MD Anderson Cancer Center, Houston, TX 77054, USA.
Toru NyunoyaDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-0688-4607

Funding

CD39-carrying extracellular vesicles regulate pulmonary thrombosis in Sickle Cell DiseaseR01HL166345 · NHLBI · VERSITI WISCONSIN, INC. · PI Prithu Sundd · 2023 to 2026
$3.1M
Role of TACC2 in smoking-induced COPDR01HL149719 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NYUNOYA, TORU · 2020 to 2023
$1.6M
BLRD VA I01 BX006096NHLBI NIH HHS R01 HL149719NHLBI NIH HHS R01 HL166345
6 · The paper itself

Abstract

Single-cell transcriptomic profiling of chronic obstructive pulmonary disease (COPD) lungs identified QKI, an RNA-binding protein, as a candidate emphysema-associated gene, but its epithelial role in COPD pathobiology remains unclear. We show that QKI expression is reduced in human COPD lungs and that alveolar type 2 epithelial (AT2) cell QKI protein levels correlate strongly with spirometric indices and diffusing capacity (DL

Identifiers

PMID42465480
PMCPMC13370942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.