Evidence map›Paper›PMID 42465465›Full record

ArticlebioRxiv : the preprint server for biology2026

A pooled image-based CRISPR screen identifies EAF1 as a

Einar B Olafsson, Christophe-Sebastien Arnold, Jacob A Kellermeier, Patrick A Rimple, Hargobinder Kaur, Yifan Wang, Jonathan Z Sexton, Staffan Svärd, Vern B Carruthers, Matthew J O'Meara

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Einar B OlafssonDepartment of Cell and Molecular Biology, Microbiology and Immunology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-3388-061X
Christophe-Sebastien ArnoldDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2392-5837
Jacob A KellermeierDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-9211-7406
Patrick A RimpleDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.ORCID 0009-0000-6834-8343
Hargobinder KaurDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-8275-2091
Yifan WangDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-9451-0041
Jonathan Z SextonDepartment of Internal Medicine, Gastroenterology and Hepatology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-9244-5888
Staffan SvärdDepartment of Cell and Molecular Biology, Microbiology and Immunology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-7392-1746
Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-6859-8895
Matthew J O'MearaGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3128-5331

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
Learning How to Give Casual Explanations for Large Scale Virtual and Morphological PharmacologyR35GM151129 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Matthew J O'Meara · 2023 to 2026
$1.5M
Laser-based high content imaging microscopeS10OD034245 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEXTON, JONATHAN ZACHARY · 2024 to 2024
$1.4M
Defining a novel protein network for Toxoplasma repurposing of host ESCRT machineryR21AI180278 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2024 to 2025
$422k
NIAID NIH HHS R21 AI180278NIAID NIH HHS T32 AI007413NIGMS NIH HHS R35 GM151129NIH HHS S10 OD034245
6 · The paper itself

Abstract

Intracellular pathogens remodel host cells by redirecting cellular machinery to the host-pathogen interface. The protozoan parasite

Indexed as

CRISPR-Cas9 screendeep learningdense granule proteinESCRThost-pathogen interactionsmachine learningmorphological profilingparasite effectorparasitophorous vacuolePythonsingle-cell imagingspatial phenotypeToxoplasma gondii

Identifiers

PMID42465465
PMCPMC13370926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.