Evidence map›Paper›PMID 42465459›Full record

ArticlebioRxiv : the preprint server for biology2026

Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration.

Stephanie L Sarbanes, Jakub Ziak, Alex L Kolodkin, Antonina Roll-Mecak

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephanie L SarbanesCell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, U.S.A.ORCID 0000-0003-0051-8523
Jakub ZiakThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 600 N. North Wolfe St., Baltimore, MD 21287, U.S.A.ORCID 0000-0001-9840-6006
Alex L KolodkinThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 600 N. North Wolfe St., Baltimore, MD 21287, U.S.A.ORCID 0000-0001-7562-5513
Antonina Roll-MecakCell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, U.S.A.ORCID 0000-0003-2621-7307

Funding

Molecular mechanisms underlying interstitial axon branching in the mammalian brainK99NS138586 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAKUB ZIAK · 2025 to 2026
$242k
The role of Poorly Characterized Disease-related Proteins in Cortical DevelopmentR03TR004616 · NCATS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2023 to 2023
$164k
Investigation of the tubulin autoregulatory response at the mechanistic level and in the human neuronFI2GM146657 · NIGMS · U.S. NATIONAL INST/NEURO/DS/STROKE · PI SARBANES, STEPHANIE LENA · 2022 to 2022
–
NCATS NIH HHS R03 TR004616NIGMS NIH HHS FI2 GM146657NINDS NIH HHS K99 NS138586
6 · The paper itself

Abstract

Microtubule dynamics regulation is critical for neuronal development, yet how neurons regulate tubulin levels remains poorly understood. Tetratricopeptide repeat domain 5 (TTC5) mediates the co-translational degradation of tubulin transcripts in response to excess soluble tubulin, a.k.a. "tubulin autoregulation", and TTC5 mutations are associated with cerebral atrophy, speech and motor impairment. Despite clinical relevance, the role of TTC5 and tubulin autoregulation in neurons has not been established. Using human induced pluripotent stem cells (iPSCs)-derived cortical-like neurons, we demonstrate that tubulin autoregulation is active in neurons and fully TTC5-dependent. Loss of TTC5 function suppresses microtubule polymerization and impairs axonal outgrowth and arborization, while enhancing cellular motility. These phenotypes recapitulate

Indexed as

cerebral atrophycortical neuron developmentintellectual disabilityiPSC-derived neuronmicrotubulesneurological diseaseneuronal differentiationneuronal migrationSCAPERTTC5tubulin autoregulation

Identifiers

PMID42465459
PMCPMC13370610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.