Evidence map›Paper›PMID 42465456›Full record

ArticlebioRxiv : the preprint server for biology2026

Mechanoresponsive modulation of nuclear pore complex structure and function by

Sunandini Chandra, Kimberly J Morgan, William L Chadwick, Megan C King, C Patrick Lusk

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sunandini ChandraDepartment of Cell Biology, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-5386-0934
Kimberly J MorganDepartment of Cell Biology, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-7871-2583
William L ChadwickDepartment of Cell Biology, Yale School of Medicine, New Haven, CT.
Megan C KingDepartment of Cell Biology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-1688-2226
C Patrick LuskDepartment of Cell Biology, Yale School of Medicine, New Haven, CT.ORCID 0000-0003-4703-0533

Funding

The mechanism of ESCRT-mediated surveillance of the nuclear envelope barrierR01GM105672 · NIGMS · YALE UNIVERSITY · PI LUSK, CHARLES PATRICK · 2013 to 2025
$4.6M
Nuclear pore complex quality control in ALS/FTDR01NS122236 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LUSK, CHARLES PATRICK, ROTHSTEIN, JEFFREY D · 2021 to 2025
$4.0M
The genetic and non-genetic responses of chromatin to forceR35GM153474 · NIGMS · YALE UNIVERSITY · PI MEGAN C KING · 2024 to 2026
$1.3M
NIGMS NIH HHS R01 GM105672NIGMS NIH HHS R35 GM153474NINDS NIH HHS R01 NS122236
6 · The paper itself

Abstract

Nuclear pore complexes (NPCs) control molecular exchange across the nuclear envelope, but how they tailor their selective permeability to meet the needs of specific cell types and/or environments remains poorly understood. We demonstrate that the strength of the NPC diffusion barrier differs across cell types, is particularly stringent in cultured neurons, and correlates with the

Identifiers

PMID42465456
PMCPMC13370948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.