Evidence map›Paper›PMID 42465454›Full record

ArticlebioRxiv : the preprint server for biology2026

HetNetEX: Exact Asymptotic Inference in Heterogeneous Biomedical Knowledge Graphs.

Tusharkanti Ghosh, Lucas A Gillenwater, Casey S Greene, James C Costello

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tusharkanti GhoshDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-7537-6374
Lucas A GillenwaterDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-6995-0130
Casey S GreeneDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-8713-9213
James C CostelloDepartment of Pharmacology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-3158-9682

Funding

Novel computational strategies to deconvolute co-occurring conditions in Down syndromeR01HD109765 · NICHD · UNIVERSITY OF COLORADO DENVER · PI James Christopher Costello, Casey S Greene · 2022 to 2026
$4.1M
NICHD NIH HHS R01 HD109765
6 · The paper itself

Abstract

Heterogeneous biomedical knowledge networks (hetnets) integrate disparate data types, drugs, genes, diseases, and pathways, across independent sources; Hetionet (https://het.io) is a widely used example. A standard approach for assessing connectivity significance is XSwap, which permutes the hetnet

Indexed as

configuration modeldegree-weighted path countdrug repurposingknowledge graphspermutation testing

Identifiers

PMID42465454
PMCPMC13370469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.