Evidence map›Paper›PMID 42465442›Full record

ArticlebioRxiv : the preprint server for biology2026

Distinct macrophage and T cell programs shape pancreatic inflammation during metabolic stress and aging.

Somesh Sai, Ibrahim Omar, Matthias Barone, Kerstin Mühle, Maria Schneider, Fenfen Liu, Sharanya Sriram, Juliette Claire Johnson, Tizia Thoma, Thomas Conrad and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Somesh SaiMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Ibrahim OmarDepartment of Pediatrics, University of California San Diego, La Jolla CA 92093-0653, USA.
Matthias BaroneBerlin Institute of Health (BIH) & Charite´ - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Kerstin MühleBerlin Institute of Health (BIH) & Charite´ - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Maria SchneiderBerlin Institute of Health (BIH) & Charite´ - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Fenfen LiuDepartment of Pediatrics, University of California San Diego, La Jolla CA 92093-0653, USA.
Sharanya SriramDepartment of Pediatrics, University of California San Diego, La Jolla CA 92093-0653, USA.
Juliette Claire JohnsonBerlin Institute of Health (BIH) & Charite´ - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Tizia ThomaBerlin Institute of Health (BIH) & Charite´ - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Thomas ConradMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Tatiana BorodinaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Birgit SawitzkiBerlin Institute of Health (BIH) & Charite´ - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Maike SanderMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Han ZhuDepartment of Pediatrics, University of California San Diego, La Jolla CA 92093-0653, USA.ORCID 0000-0003-1896-7140

Funding

Promotion of beta cell proliferation by epigenetically reprogrammed macrophagesR01DK114427 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDER, MAIKE · 2018 to 2022
$1.9M
Gene regulatory programs drivingmetabolic maturation of human pluripotent stem cell derived β-cellsR03DK138495 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ZHU, HAN · 2024 to 2025
$314k
NIDDK NIH HHS R01 DK114427NIDDK NIH HHS R03 DK138495
6 · The paper itself

Abstract

Type 2 diabetes is linked to systemic inflammation driven by metabolic stress and aging. Although pancreatic inflammation associated with these factors is well documented, the dynamics of immune cell populations and their molecular changes remain poorly understood. We characterized immune cell alterations in the pancreas and pancreatic islets during Western diet (WD) feeding and aging using imaging mass cytometry (IMC) and single-cell RNA sequencing (scRNA-seq). Spatial and transcriptional analyses were performed to define immune cell subtype composition, activation states, and inferred cell-cell communication programs under metabolic and age-related stress conditions. Our analyses identified expansion of an F4/80

Identifiers

PMID42465442
PMCPMC13370470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.