Evidence map›Paper›PMID 42465437›Full record

ArticlebioRxiv : the preprint server for biology2026

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions.

Priyanka Madhu, Caroline Benz, Leandro Simonetti, Matthew J Winters, Mythili S Subbanna, Johanna Kliche, Lidia Gomez-Lucas, Hazem M Kotb, Izabella Krystkowiak, Dmitri Segal and 26 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Priyanka MadhuDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.
Caroline BenzDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0002-5166-3598
Leandro SimonettiDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0003-1283-9770
Matthew J WintersDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mythili S SubbannaDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Johanna KlicheDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0003-3179-4635
Lidia Gomez-LucasDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.
Hazem M KotbDivision of Cancer Biology, The Institute of Cancer Research, London, UK.
Izabella KrystkowiakDivision of Cancer Biology, The Institute of Cancer Research, London, UK.
Dmitri SegalDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada.ORCID 0000-0003-0880-4794
William T P DarlingDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0009-0009-3161-8210
Sven Larsen-LedetDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5167-4636
Maximilian VielerDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0002-3617-1018
Ana ZupancicDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0009-0003-3282-2826
Aimiliani KonstantinouDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0009-0009-6955-9906
Filip MihalicDepartment of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, 751 23 Uppsala, Sweden.ORCID 0000-0002-6840-2319
Julia K VargaCenter for Computational Medicine, Departments of Quantitative Molecular Medicine (QMM) & Microbiology and Molecular Genetics, IMRIC, The Hebrew University of Jerusalem, Israel.ORCID 0000-0002-5318-2798
Livia PaganoDipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.ORCID 0000-0003-1923-8126
Susanne LüchowDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0002-4916-3324
Andreas KraemerInstitute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Lachlan EllingboeDivision of Cancer Biology, The Institute of Cancer Research, London, UK.ORCID 0009-0006-2484-4509
Kristof GörlitzDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.
Germanna L RighettoStructural Genomics Consortium, Toronto, ON, Canada.
Christin KossmannDepartment of Drug Design and Pharmacology, Center for Biopharmaceuticals, University of Copenhagen, Copenhagen, Denmark.
Ruisheng XiongDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.
Ora Schueler-FurmanCenter for Computational Medicine, Departments of Quantitative Molecular Medicine (QMM) & Microbiology and Molecular Genetics, IMRIC, The Hebrew University of Jerusalem, Israel.ORCID 0000-0002-1624-0362
Levon HalabelianStructural Genomics Consortium, Toronto, ON, Canada.ORCID 0000-0003-4361-3619
Vijayaratnam SanthakumarStructural Genomics Consortium, Toronto, ON, Canada.ORCID 0000-0002-7001-557X
Cheryl ArrowsmithStructural Genomics Consortium, Toronto, ON, Canada.ORCID 0000-0002-4971-3250
Stefan KnappInstitute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.ORCID 0000-0001-5995-6494
Mate ErdelyiDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0003-0359-5970
Amelie SteinDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
Renaud VincentelliAix Marseille Université, Centre National de la Recherche Scientifique, AFMB, Marseille, France.
Peter M PryciakDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Norman E DaveyDivision of Cancer Biology, The Institute of Cancer Research, London, UK.ORCID 0000-0001-6988-4850
Ylva IvarssonDepartment of Chemistry for Life Sciences, Uppsala University, Husargatan 3, Box 576, 751 23 Uppsala, Sweden.ORCID 0000-0002-7081-3846

Funding

YEAST PHEROMONE SIGNAL TRANSDUCTIONR01GM057769 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PRYCIAK, PETER M · 1997 to 2023
$7.6M
Comprehensive Analysis of Peptide Motif Binding In VivoR01GM145795 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PRYCIAK, PETER M · 2022 to 2025
$1.3M
NIGMS NIH HHS R01 GM057769NIGMS NIH HHS R01 GM145795
6 · The paper itself

Abstract

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology

Indexed as

IDRsIntrinsically Disordered RegionsMotif-based Recognitionproteome-scale interactomeShort Linear Motifs (SLiMs)Transient Protein Interactions

Identifiers

PMID42465437
PMCPMC13370473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.