Evidence map›Paper›PMID 42465413›Full record

ArticlebioRxiv : the preprint server for biology2026

MDA5 and the integrated stress response control sex-specific type 1 diabetes onset in NOD mice.

Erik Van Dis, Alessandra T DeGidio, Lara Yao, Damion Winship, Carmela Sidrauski, Jacquelyn A Gorman, Daniel B Stetson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erik Van DisDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.ORCID 0000-0003-4773-379X
Alessandra T DeGidioDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
Lara YaoDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
Damion WinshipDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
Carmela SidrauskiCalico Life Sciences LLC, South San Francisco, CA 94080, USA.
Jacquelyn A GormanOklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK 73104, USA.
Daniel B StetsonDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.

Funding

Intracellular nucleic acid detection in autoimmunityR01AI084914 · NIAID · UNIVERSITY OF WASHINGTON · PI STETSON, DANIEL B · 2010 to 2024
$7.2M
NIAID NIH HHS R01 AI084914
6 · The paper itself

Abstract

Type I diabetes (T1D) is an autoimmune disorder in which the insulin producing cells of the pancreas are attacked and destroyed by autoreactive T cells. The innate immune mechanisms that contribute to T1D remain incompletely defined. Genome-wide association studies in humans have identified alleles of the

Identifiers

PMID42465413
PMCPMC13370428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.