Evidence map›Paper›PMID 42465396›Full record

ArticlebioRxiv : the preprint server for biology2026

Biophysical properties of IgD determine thresholds for self-tolerance and selection into germinal centers.

Lachlan P Deimel, Ryan A Brady, Andriy Goychuk, Gabriela S Silva Santos, Clara Uhe, Andrew J MacLean, Brianna Hernandez, Shuai Zong, Laurine Binet, Mary Tenuta and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lachlan P DeimelLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3803-871X
Ryan A BradyDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Andriy GoychukDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gabriela S Silva SantosLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Clara UheLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Andrew J MacLeanLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Brianna HernandezLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Shuai ZongLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Laurine BinetLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Mary TenutaLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Dennis Shaefer-BabajewLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Zeliha KilicDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anna GazumyanLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Thiago Y OliveiraLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Harald HartwegerLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Arup K ChakrabortyDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Scott C BlanchardDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2717-9365
Michel C NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
Stuctural basis of bNab activityP01AI100148 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Pamela J Bjorkman · 2013 to 2026
$43.3M
Class Switch Recombination in B LymphocytesR37AI037526 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2014 to 2023
$5.4M
NCI NIH HHS P30 CA008748NIAID NIH HHS P01 AI100148NIAID NIH HHS R37 AI037526NIAID NIH HHS UM1 AI144462
6 · The paper itself

Abstract

Immunoglobulin D (IgD) is among the most conserved antibody isotypes, found in virtually all jawed vertebrates

Identifiers

PMID42465396
PMCPMC13370332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.