Evidence map›Paper›PMID 42465393›Full record

ArticlebioRxiv : the preprint server for biology2026

Hepatic stearoyl-CoA desaturase deficiency ameliorates hyperglycemia through bile acid signaling in an insulin-independent manner.

Mugagga Kalyesubula, Daehan Kim, Woo Sung Kim, Nicole B Wicker, Jonathan Williams, Veronica P Christofi, Ethan Anderson, Jacqueline R Miller, Dylan Cootway, Kaela Groppel and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mugagga KalyesubulaDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Daehan KimDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Woo Sung KimDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Nicole B WickerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Jonathan WilliamsDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Veronica P ChristofiDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Ethan AndersonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Jacqueline R MillerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Dylan CootwayDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Kaela GroppelDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Daniel BergmanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Snehal N ChaudhariDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
James M NtambiDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.

Funding

Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Chemistry-Biology Interface Training ProgramT32GM152341 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2024 to 2026
$1.6M
Role of Liver Stearoyl-CoA Desaturase-1 in the Regulation of MetabolismR01DK118093 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI NTAMBI, JAMES M. · 2018 to 2020
$1.1M
Elucidating the role of the microbiome in inducing gut permeability and inflammationR00DK128503 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Snehal N. Chaudhari · 2024 to 2026
$727k
NIA NIH HHS T32 AG000213NIDDK NIH HHS R00 DK128503NIDDK NIH HHS R01 DK118093NIGMS NIH HHS T32 GM135066NIGMS NIH HHS T32 GM152341
6 · The paper itself

Abstract

Hyperglycemia in Type 1 Diabetes (T1D) is managed almost exclusively via exogenous insulin therapy, an approach restricted by significant glycemic fluctuations, long-term side effects such as weight gain, and high economic burden. Identifying physiological pathways capable of clearing blood glucose independent of insulin is therefore of paramount clinical importance. Here, we demonstrate that liver-specific stearoyl-CoA desaturase-1 (SCD1) deficiency protects against diabetic hyperglycemia and hepatic steatosis in an insulin-independent manner. SCD1 ablation decreases cellular oleate availability, altering lipid flux and redirecting excess cholesterol into alternative biosynthetic pathways. This redirection drives a 2-fold elevation in hepatic bile acids and a striking 10-fold increase in plasma bile acids, predominantly characterized by the accumulation of taurocholic acid. This shifted bile acid pool stimulates the expression of glucose transporter 1 (

Identifiers

PMID42465393
PMCPMC13370891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.