Evidence map›Paper›PMID 42465385›Full record

ArticlebioRxiv : the preprint server for biology2026

OpenEvo: An Open-Source Platform for Automated Evolution and Analysis.

Sebastian S Cocioba, Pin-Che Huang, John Mallon, Zane Chan, Amanuel W Geremew, Alex Bisson, Phillip Kyriakakis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sebastian S CociobaBinomica Labs, 43-01 22nd Street, 3rd Floor Suite 342, Long Island City, NY 11101.ORCID 0000-0002-6821-2996
Pin-Che HuangDepartment of Medical Science, National Tsing Hua University, Hsinchu, 300044, Taiwan.ORCID 0009-0007-4146-4281
John MallonDepartment of Biology, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-3912-206X
Zane ChanDepartment of Mathematics, Stanford University, Stanford, CA, 94305.ORCID 0009-0009-3955-1655
Amanuel W GeremewDepartment of Bioengineering, Stanford University, Stanford, CA, 94305.ORCID 0009-0009-9979-2151
Alex BissonDepartment of Biology, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-5940-7230
Phillip KyriakakisDepartment of Mathematics, Stanford University, Stanford, CA, 94305.ORCID 0000-0002-0465-8251

Funding

Archaea as a microbial model for developmental mechanoplasticityR35GM156992 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Alexandre W Bisson Filho · 2025 to 2026
$793k
Programmable evolution of optogenetic systemsR21GM143806 · NIGMS · STANFORD UNIVERSITY · PI COLEMAN, TODD P, KYRIAKAKIS, PHILLIP · 2021 to 2022
$456k
NIGMS NIH HHS R21 GM143806NIGMS NIH HHS R35 GM156992
6 · The paper itself

Abstract

Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-source hardware; OpenEvo addresses this gap with a complete, fully automated evolution platform with detailed, illustrated construction instructions for beginners, open-source software and firmware, priced around $300. An optional PC-based interface offers enhanced functionality, including remote access, programmable evolution cycles, programmable LED stimulation, and a data visualization tool. OpenEvo can cycle through three types of media for positive, negative, and neutral selection conditions, supporting a wide range of experimental designs. We validate the use of OpenEvo by evolving

Identifiers

PMID42465385
PMCPMC13370392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.