Evidence map›Paper›PMID 42465381›Full record

ArticlebioRxiv : the preprint server for biology2026

Xeno-Free Peptide-Functionalized Hydrogels Support hiPSC Encapsulation and

Mohammadjafar Hashemi, Nongmaithem Debeni Devi, Yasaman Kargar Gaz Kooh, Charlotte Chen, Bahareh Bahmani, Ganesh Malayath, Julia Victor, Nathaniel Huebsch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammadjafar HashemiDepartment of Biomedical Engineering, Washington University in St. Louis, USA.ORCID 0000-0003-0526-0592
Nongmaithem Debeni DeviDepartment of Biomedical Engineering, Washington University in St. Louis, USA.ORCID 0009-0000-8001-9534
Yasaman Kargar Gaz KoohInstitute of Materials Science and Engineering, Washington University in St. Louis, USA.ORCID 0009-0005-3257-2921
Charlotte ChenDepartment of Biomedical Engineering, Washington University in St. Louis, USA.ORCID 0009-0002-3010-2027
Bahareh BahmaniDepartment of Biomedical Engineering, Washington University in St. Louis, USA.ORCID 0000-0001-6966-6685
Ganesh MalayathDepartment of Biomedical Engineering, Washington University in St. Louis, USA.ORCID 0000-0003-3455-7512
Julia VictorDepartment of Biomedical Engineering, Washington University in St. Louis, USA.
Nathaniel HuebschDepartment of Biomedical Engineering, Washington University in St. Louis, USA.ORCID 0000-0002-3329-0214

Funding

ROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9M
TRAINING IN REGENERATIVE MEDICINET32EB028092 · NIBIB · WASHINGTON UNIVERSITY · PI Farshid Guilak · 2020 to 2026
$2.0M
Biomaterial Platforms to Model the Role of Mechanical Overload in MYBPC3-Linked Hypertrophic CardiomyopathyR01HL159094 · NHLBI · WASHINGTON UNIVERSITY · PI HUEBSCH, NATHANIEL · 2021 to 2025
$2.0M
Alginate Hydrogels with Tethered IGF-1 Mimicking Peptides to enhance the Therapeutic Potency of Mesenchymal Stem Cells for Intervertebral Disc RepairR21AR082992 · NIAMS · WASHINGTON UNIVERSITY · PI HUEBSCH, NATHANIEL · 2024 to 2024
$376k
NHLBI NIH HHS R01 HL107594NHLBI NIH HHS R01 HL159094NIAMS NIH HHS R21 AR082992NIBIB NIH HHS T32 EB028092
6 · The paper itself

Abstract

While defined synthetic substrates can replace Matrigel for human induced pluripotent stem cell (hiPSC) culture and hiPSC-derived cardiomyocyte (hiPSC-CM) production, existing approaches culture cells on two-dimensional surfaces and yield structurally immature cardiomyocytes, limiting their use in disease modeling and regenerative medicine. Here, we developed a xeno-free, fully-defined cyclic RGD (cRGD)-functionalized alginate platform in which we encapsulated hiPSCs to support their expansion and

Indexed as

AlginatehiPSC-CMHuman Induced Pluripotent Stem Cellsstem cell encapsulationsuspension differentiation

Identifiers

PMID42465381
PMCPMC13370368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.