Evidence map›Paper›PMID 42465373›Full record

ArticlebioRxiv : the preprint server for biology2026

Efficient Endogenous Tagging in the Sea Urchin,

Yoon Lee, Chloe Jenniches, Svenja Kling, Evan Tjeerdema, Elliot Jackson, Alexandre Paix, Amro Hamdoun

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yoon LeeCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-0147-3208
Chloe JennichesCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0009-0000-9955-393X
Svenja KlingCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-5109-2521
Evan TjeerdemaCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-3732-9232
Elliot JacksonCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-4213-3851
Alexandre PaixDepartment of Algal Development and Evolution, Max Planck Institute for Biology, Max-Planck-Ring 5, Tübingen, 72076, Germany.ORCID 0000-0002-8080-7546
Amro HamdounCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-2568-048X

Funding

The National Sea Urchin Resource Center (NSURC): A resource for foundational sea urchin linesR24OD037824 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMRO M HAMDOUN, Deirdre C Lyons · 2025 to 2026
$1.5M
NIH HHS R24 OD037824
6 · The paper itself

Abstract

Precise knock-in of fluorescent reporters is a powerful tool for studying the dynamic cellular and molecular processes of embryogenesis. However, conventional CRISPR-Cas9 knock-in of large inserts, such as full-length fluorescent proteins, is inefficient. This has limited its application in many emerging model systems, including sea urchins. Here, we overcome this barrier using a transgenic

Indexed as

CRISPR-Cas9 knock-inhomology directed repairLytechinus pictussea urchinsplit-fluorescent proteinssODNtransgenic

Identifiers

PMID42465373
PMCPMC13370504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.