ArticlebioRxiv : the preprint server for biology2026
Frontal Eye Field Leads a Distributed Oculomotor Circuit for Abstract Categorical Decisions.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Flexible decisions require the brain to transform sensory evidence into abstract, task-relevant variables and then into actions. Understanding this process requires identifying how distributed neural populations represent sensory, cognitive, and motor variables, and how interareal interactions mediate transformations between them. We simultaneously recorded population activity in frontal eye field (FEF), lateral intraparietal area (LIP) and superior colliculus (SC) while monkeys performed a flexible yet urgent visual motion-categorization task. Within this network, FEF first encoded abstract categories, followed by SC and then LIP. LIP showed the earliest encoding of visual stimulus features, but a later encoding of upcoming saccades. Single-trial analyses revealed directed information flow from FEF to LIP populations for category- and choice-related signals. Reversible FEF inactivation impaired categorization and saccadic choice, causally implicating FEF in category-guided action. These findings reveal a differentiated FEF-LIP-SC circuit for transforming sensory evidence into abstract categorical decisions and the actions used to report them.
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