ArticlebioRxiv : the preprint server for biology2026
Scanning transcriptomes for nonlinear, domain-level similarities using hmSEEKR.
Shuang Li, Daniel A Sprague, Quinn E Eberhard, Samuel P Boyson, Alain Laederach, J Mauro Calabrese
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors.
Daniel A SpragueDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599.
Quinn E EberhardDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599.
Samuel P BoysonDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599.
Funding
Non-coding RNA structure change in Chronic Obstructive Pulmonary DiseaseR01HL111527 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alain T Laederach, Kevin M Weeks · 2012 to 2026
$6.6MPREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIST32GM007040 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS, ROBERT A · 1985 to 2019
$6.0MNRSA in GeneticsT32GM135128 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay, JEFF J. SEKELSKY · 2020 to 2026
$5.1MMechanisms of gene silencing induced by long noncoding RNAsR01GM121806 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CALABRESE, JOSEPH MAURO · 2017 to 2023
$2.3MVariant induced RNA structure change in human genetic diseaseR35GM140844 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAEDERACH, ALAIN T · 2021 to 2025
$2.1MMechanisms of gene regulation by long noncoding RNAsR35GM153293 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Mauro Calabrese · 2024 to 2026
$1.9MCooperative control of Polycomb Repressive Complexes by long noncoding RNAs, CpG island DNA, and RNA-binding proteinsR01GM136819 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CALABRESE, JOSEPH MAURO · 2020 to 2023
$1.5MComputational tools to study relationships between sequence, structure, and function in lncRNAsF31HG014413 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Quinn Elise Eberhard · 2025 to 2026
$82kNHGRI NIH HHS F31 HG014413NHLBI NIH HHS R01 HL111527NIGMS NIH HHS R01 GM121806NIGMS NIH HHS R01 GM136819NIGMS NIH HHS R35 GM140844NIGMS NIH HHS R35 GM153293NIGMS NIH HHS T32 GM007040NIGMS NIH HHS T32 GM135128
6 · The paper itselfAbstract
Long noncoding RNAs (lncRNAs) play roles in gene regulation across kingdoms of life. However, lncRNAs with related functions often lack linear sequence similarity, making it difficult to leverage studies of one lncRNA to inform the understanding of others. We describe a
Identifiers
PMID42465344
PMCPMC13370960
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