Evidence map›Paper›PMID 42465339›Full record

ArticlebioRxiv : the preprint server for biology2026

Dopamine Abundance Uncouples Neurodegeneration and Lifespan in a

Corey W Willicott, Tyler J Altman, Logan C Kimble, Laura A Berkowitz, Guy A Caldwell, Kim A Caldwell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Corey W WillicottDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0009-0005-3939-0370
Tyler J AltmanDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0000-0002-1544-9666
Logan C KimbleDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0009-0002-6711-6895
Laura A BerkowitzDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0000-0002-4238-0326
Guy A CaldwellDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0000-0002-8283-9090
Kim A CaldwellDepartment of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0000-0003-1580-6122

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Functional Analysis Of The Intersection of Mitochondrial Stress and NeurodegenerationR15NS106460 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI CALDWELL, KIM A · 2018 to 2020
$556k
NIH HHS P40 OD010440NINDS NIH HHS R15 NS106460
6 · The paper itself

Abstract

The neuropathology of Parkinson's disease is characterized by α-synuclein (α-syn) aggregation and dopaminergic (DAergic) neurodegeneration. While neuronal loss in

Indexed as

alpha-synucleinautophagybetaineclomipraminedopaminehlh-30lifespanneurodegeneration

Identifiers

PMID42465339
PMCPMC13371039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.