Evidence map›Paper›PMID 42465324›Full record

ArticlebioRxiv : the preprint server for biology2026

Region-Level Design and Analysis of CRISPR Perturbation Screens with FRACTEL.

Richard W Doty, Maria A Ter Weele, Alejandro Barrera, Lexi R Bounds, Charles A Gersbach, Andrew S Allen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Richard W DotyDepartment of Biostatistics & Bioinformatics, Duke University, Durham, 27705, NC, USA.ORCID 0000-0003-4197-4920
Maria A Ter WeeleCenter for Advanced Genomic Technologies, Duke University, Durham, 27705, NC, USA.
Alejandro BarreraCenter for Advanced Genomic Technologies, Duke University, Durham, 27705, NC, USA.
Lexi R BoundsCenter for Advanced Genomic Technologies, Duke University, Durham, 27705, NC, USA.ORCID 0000-0002-4734-3743
Charles A GersbachCenter for Advanced Genomic Technologies, Duke University, Durham, 27705, NC, USA.ORCID 0000-0003-1478-4013
Andrew S AllenDepartment of Biostatistics & Bioinformatics, Duke University, Durham, 27705, NC, USA.ORCID 0000-0002-7232-2143

Funding

High-Throughput Functional Annotation of Gene Regulatory Elements and Variants Critical to Complex Cellular PhenotypesUM1HG012053 · NHGRI · DUKE UNIVERSITY · PI GREGORY E CRAWFORD, Charles A. Gersbach · 2021 to 2026
$10.7M
Design, prediction, and prioritization of systematic perturbations of the human genomeU01HG011967 · NHGRI · DUKE UNIVERSITY · PI ANDREW S ALLEN, William Majoros · 2021 to 2026
$3.9M
NHGRI NIH HHS U01 HG011967NHGRI NIH HHS UM1 HG012053
6 · The paper itself

Abstract

We present FRACTEL, a statistical framework for region-level analysis of CRISPR perturbation screens. FRACTEL aggregates gRNA

Indexed as

CRISPR analysispower analysisregion-level inferencerobust rank aggregation

Identifiers

PMID42465324
PMCPMC13371058

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.