Evidence map›Paper›PMID 42465323›Full record

ArticlebioRxiv : the preprint server for biology2026

Madhulika Rai, Shefali A Shefali, Jason P Tourigny, Minseo Kim, Travis Nemkov, Angelo D'Alessandro, Jason M Tennessen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madhulika RaiDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0003-0228-285X
Shefali A ShefaliDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0001-8334-5351
Jason P TourignyDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Minseo KimDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0009-0004-5891-7329
Travis NemkovDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-8566-7119
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-2258-6490
Jason M TennessenDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-3527-5683

Funding

Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
A Drosophila Model for the Regulation of Aerobic GlycolysisR35GM119557 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Jason Michael Tennessen · 2016 to 2026
$4.7M
Investigating metabolic responses to high sugar diets and the onset of diabetic phenotypesR01DK136945 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI Angelo D'Alessandro, NORBERT PERRIMON · 2023 to 2026
$2.4M
NHGRI NIH HHS U41 HG000739NIDDK NIH HHS R01 DK136945NIGMS NIH HHS R35 GM119557NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme that commonly exhibits altered expression in human diseases such as cancers and neurodegeneration, making it a valuable disease biomarker and putative therapeutic target. However, any treatment targeting LDHA will also disrupt normal metabolism, underscoring the need to investigate physiological consequences of inhibiting this enzyme. We previously established the fruit fly

Indexed as

DrosophilaExercise IntoleranceGlycogen Storage Disease Type XILactate dehydrogenaseMetabolism

Identifiers

PMID42465323
PMCPMC13370976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.