Evidence map›Paper›PMID 42465283›Full record

ArticlebioRxiv : the preprint server for biology2026

A nitrite-responsive regulatory RNA locus sustains commensal resilience against nitrosative stress.

Ryan T Fansler, Daniel W Bak, Madison Langford-Butler, Liang Chen, Deepanshu Singla, Luisella Spiga, Jonathan Livny, John Karijolich, Chance Meers, Qiangjun Zhou and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ryan T FanslerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Daniel W BakDepartment of Chemistry, Boston College, Chestnut Hill, MA.
Madison Langford-ButlerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Liang ChenDepartment of Cell and Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, TN.
Deepanshu SinglaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Luisella SpigaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Jonathan LivnyInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA.
John KarijolichDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Chance MeersDepartment of Biochemistry, Vanderbilt University, Nashville, TN.
Qiangjun ZhouDepartment of Cell and Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, TN.
Eranthie WeerapanaDepartment of Chemistry, Boston College, Chestnut Hill, MA.
Wenhan ZhuDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.

Funding

Developing chemical-proteomic tools to investigate cysteine oxidationR35GM134964 · NIGMS · BOSTON COLLEGE · PI WEERAPANA, ERANTHIE · 2020 to 2024
$3.1M
Commensal resilience mechanisms in the inflamed intestineR35GM147470 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2022 to 2026
$2.2M
Synaptic nanostructure and dysfunction in neurodevelopmental disordersR01MH132918 · NIMH · VANDERBILT UNIVERSITY · PI Qiangjun Zhou · 2024 to 2026
$1.8M
Commensal bacteria resilience mechanisms in the inflamed intestineR01DK134692 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2023 to 2026
$1.4M
Turicibacter modifies intestinal infection severity by modulating intestinal metabolitesR21AI187749 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2025 to 2026
$481k
Bacterial membrane fusion sustains commensal resilience during enteric pathogen infectionR21AI199418 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2026 to 2026
$275k
Iron homeostasis in sustaining commensal resilience in the inflamed gutF31AI178950 · NIAID · VANDERBILT UNIVERSITY · PI Ryan T Fansler · 2024 to 2026
$105k
NIAID NIH HHS F31 AI178950NIAID NIH HHS R21 AI187749NIAID NIH HHS R21 AI199418NIDDK NIH HHS R01 DK134692NIGMS NIH HHS R35 GM134964NIGMS NIH HHS R35 GM147470NIMH NIH HHS R01 MH132918
6 · The paper itself

Abstract

Commensal microbes in the gastrointestinal tract are central to host health, yet they must adapt to frequent perturbations such as intestinal inflammation that challenges microbial homeostasis. A major challenge during inflammation is exposure to host-derived reactive nitrogen species (RNS), which damage macromolecules and impair microbial fitness, but how commensals orchestrate defense against nitrosative stress remains poorly defined. Here, we show that

Identifiers

PMID42465283
PMCPMC13370916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.