Evidence map›Paper›PMID 42465274›Full record

ArticlebioRxiv : the preprint server for biology2026

The DUF998 family protein DrmA modulates cationic glycolipid levels and the emergence of high-level daptomycin resistance in

Aparna Uppuluri, Jonathan Martin, Luke R Joyce, Tata Ninidze, Kelly S Doran, Faruck Morcos, Ziqiang Guan, Kelli L Palmer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aparna UppuluriDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas.
Jonathan MartinDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas.
Luke R JoyceDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-9346-671X
Tata NinidzeSchool of Natural Sciences and Medicine, Ilia State University, Tbilisi, Georgia.
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Faruck MorcosDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas.ORCID 0000-0001-6208-1561
Ziqiang GuanDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina.ORCID 0000-0002-8082-3423
Kelli L PalmerDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas.ORCID 0000-0002-7343-9271

Funding

Roles of novel cationic lipids in bacterial pathogenesisR01AI178692 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI Kelly S Doran, Ziqiang Guan · 2023 to 2026
$2.6M
Adaptive alterations of lipids in mitis group streptococciR01AI148366 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI GUAN, ZIQIANG, PALMER, KELLI LEA · 2020 to 2024
$2.5M
NIAID NIH HHS R01 AI148366NIAID NIH HHS R01 AI178692
6 · The paper itself

Abstract

Daptomycin resistance (DAP-R) in enterococci is associated with alterations in the membrane lipid composition. The membrane-bound protein MprF is responsible for the synthesis of amino acid-modified lipids in bacteria, and these modified lipids contribute to DAP-R in some Gram-positive pathogens. In enterococci, MprF synthesizes three lysine-modified lipids: the phospholipid lysyl-phosphatidylglycerol (Lys-PG), and the newly identified cationic glycolipids lysyl-diglucosyl-diacylglycerol (Lys-Glc

Identifiers

PMID42465274
PMCPMC13370385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.