Evidence map›Paper›PMID 42465269›Full record

ArticlebioRxiv : the preprint server for biology2026

RNA and proteins joined up at the Origins of Life: Persistence is the point.

Mohamed Swailem, Ken A Dill

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mohamed SwailemLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-4590-675X
Ken A DillLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-2390-2002

Funding

Solvation modeling for next-gen biomolecule simulationsRM1GM135136 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI COUTSIAS, EVANGELOS A., DILL, KEN A · 2020 to 2024
$6.0M
NIGMS NIH HHS RM1 GM135136
6 · The paper itself

Abstract

What drove nucleic acids (NA) to associate with proteins (PR) at the Origins of Life? We reason from polymer physics and the Central Dogma (CD) that the fitness value of cooperating through a division of labor - NA for replication fidelity and PR for functional fitness - is much higher than for either polymer alone. Our model shows a Pareto Front, where NA and PR can bootstrap each other to achieve autocatalytic cooperativity towards biology.

Identifiers

PMID42465269
PMCPMC13370373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.