Evidence map›Paper›PMID 42465261›Full record

ArticlebioRxiv : the preprint server for biology2026

SLC16A6 is a tyrosine transporter for the melanosome.

Corey N Cunningham, Alex J Bott, Charles H Adelmann, Matthew Shields, Katarina E Heyden, Jonathan G Van Vranken, Álvaro Jesús Narbona-Pérez, Juan A Cantres-Vélez, Guillaume Adelmant, Nathan M Krah and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Corey N CunninghamDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0000-0002-1755-4881
Alex J BottDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0000-0003-2273-8922
Charles H AdelmannCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114 USA.ORCID 0000-0001-7823-4374
Matthew ShieldsDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.
Katarina E HeydenDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0000-0002-4731-6825
Jonathan G Van VrankenDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115 USA.ORCID 0000-0002-8931-852X
Álvaro Jesús Narbona-PérezDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0000-0002-1517-6610
Juan A Cantres-VélezDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0000-0002-2069-4690
Guillaume AdelmantIOCB Prague & Boston, Prague, CZ & Boston, USA.ORCID 0000-0003-4075-5486
Nathan M KrahDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0009-0003-8297-7359
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115 USA.ORCID 0000-0001-7626-0034
David M SabatiniIOCB Prague & Boston, Prague, CZ & Boston, USA.ORCID 0000-0002-1446-7256
Jared RutterDepartment of Biochemistry, University of Utah Medical School, Salt Lake City, UT 84112 USA.ORCID 0000-0002-2710-9765

Funding

Mitochondrial Biochemistry: From Mechanisms to DiseaseR35GM131854 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 2019 to 2026
$3.3M
Agilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578k
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
Agilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401k
Myc-induced expression of glutamine synthetaseK00CA212445 · NCI · UNIVERSITY OF UTAH · PI BOTT, ALEX · 2018 to 2021
$367k
Defining intracellular mitochondrial heterogeneity establishment and maintenanceF32GM140525 · NIGMS · UNIVERSITY OF UTAH · PI CUNNINGHAM, COREY NATHANIEL · 2021 to 2022
$134k
Non-canonical transcriptional activation of MITF in pigment cells.K99AR084551 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Charles Hank Adelmann · 2026 to 2026
$108k
NCI NIH HHS K00 CA212445NIAMS NIH HHS K99 AR084551NIGMS NIH HHS F32 GM140525NIGMS NIH HHS R35 GM131854NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD021505
6 · The paper itself

Abstract

Cells enable specialized metabolism by compartmentalizing metabolic pathways into distinct organelles, which requires the membrane transport of metabolites. In melanocytes, the amino acid tyrosine is imported into developing melanosomes for the synthesis of the UV-protective pigment melanin

Identifiers

PMID42465261
PMCPMC13370447

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.