Evidence map›Paper›PMID 42465243›Full record

ArticlebioRxiv : the preprint server for biology2026

PIP

Giusy A Caprara, Sujin Jun, Ye-Ri Kim, Gabriel J Olguín-Orellana, Yein Christina Park, Claudia Martínez-García, Sihan Li, Angela Ballesteros, David Ramírez, Unkyung Kim and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giusy A CapraraDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0002-9609-0789
Sujin JunDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Ye-Ri KimDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Gabriel J Olguín-OrellanaDepartamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, 4030000, Chile.
Yein Christina ParkSection on Sensory Physiology and Biophysics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD.
Claudia Martínez-GarcíaDepartamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, 4030000, Chile.
Sihan LiDepartment of Neuroscience, University of Virginia, Charlottesville, VA.ORCID 0000-0001-5396-6181
Angela BallesterosSection on Sensory Physiology and Biophysics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-5796-6875
David RamírezDepartamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, 4030000, Chile.
Unkyung KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea.
Jung-Bum ShinDepartment of Neuroscience, University of Virginia, Charlottesville, VA.ORCID 0000-0003-3047-0874
Anthony W PengDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0002-2208-6779

Funding

Molecular mechanisms of cochlear hair bundle mechanicsR01DC016868 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Anthony Wei Peng · 2018 to 2026
$4.1M
Role of XIRP2 in hair cell function and degenerationR01DC014254 · NIDCD · UNIVERSITY OF VIRGINIA · PI SHIN, JUNG-BUM · 2015 to 2019
$1.7M
Investigating the molecular mechanism of slow adaptationR21DC019701 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI CAPRARA, GIUSY A · 2021 to 2022
$311k
NIDCD NIH HHS R01 DC014254NIDCD NIH HHS R01 DC016868NIDCD NIH HHS R21 DC019701
6 · The paper itself

Abstract

Sensory hair cells detect sound and balance through their apically located stereocilia bundles, converting mechanical stimuli into electrical signals via mechano-electrical transduction (MET) channels. These channels at the lower end of extracellular tip links connecting adjacent stereocilia are gated by tension. A key regulatory process of MET is

Identifiers

PMID42465243
PMCPMC13370362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.