Evidence map›Paper›PMID 42465233›Full record

ArticlebioRxiv : the preprint server for biology2026

Multiple evolutionary routes to cytoskeletal arborization revealed by the rhizarian amoeba

Sarah L Guest, Scott C Dawson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah L GuestUniversity of Massachusetts Amherst, Department of Biology, 611 N. Pleasant St., Amherst MA 01003.ORCID 0000-0001-9020-2631
Scott C DawsonUniversity of California, Davis; Department of Microbiology and Molecular Genetics One Shields Avenue, Davis, CA 95616.ORCID 0000-0002-0843-1759

Funding

Molecular mechanisms of attachment by the ventral disc in GiardiaR01AI077571 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DAWSON, SCOTT C · 2009 to 2023
$5.9M
NIAID NIH HHS R01 AI077571
6 · The paper itself

Abstract

The eukaryotic cytoskeleton generates remarkable diversity in cellular architecture despite being built from deeply conserved actin and tubulin polymers. Diversification of cytoskeletal regulators, motors, and filament-organizing proteins produces highly varied cellular morphologies across eukaryotes, yet certain higher-order architectures repeatedly emerge in distantly related lineages. One notable example is cytoskeletal arborization, which occurs not only in metazoan neurons but also in amoeboid lineages distributed throughout the eukaryotic tree. Whether these similar branched architectures arise through conserved cytoskeletal organization, independent reuse of shared molecular systems, or convergence driven by common physical constraints remains unresolved. Here, we investigate the rhizarian amoeba

Identifiers

PMID42465233
PMCPMC13371060

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.