ArticleFrontiers in medicine2026
VISULYZE-assisted nomogram optimization enhances astigmatism correction accuracy in keratorefractive lenticule extraction: a stratified retrospective analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Keratorefractive lenticule extraction (KLEx) commonly relies on empirical nomogram adjustments to improve refractive accuracy; however, astigmatism correction remains suboptimal. VISULYZE (Carl Zeiss Meditec AG) enables data-driven nomogram optimization, but its differential effectiveness across astigmatism severities has not been fully characterized. This study compared VISULYZE-assisted nomogram optimization with empirical nomogram adjustment for spherical and astigmatic correction, using stratified vector analysis to quantify gains in precision. Methods: This retrospective case-control study included 206 eyes that underwent KLEx between December 2023 and July 2024 and completed a minimum 3-month follow-up. Eyes were assigned to either VISULYZE-assisted nomogram optimization (VISULYZE group, Results: At 3 months, 100% of eyes in the VISULYZE group achieved a UDVA of 20/20 or better, compared with 98% of control eyes; furthermore, 87% of the VISULYZE group vs. 73% of the control group achieved 20/16 or better ( Conclusion: VISULYZE-assisted nomogram optimization improved the accuracy of both spherical and astigmatic correction in KLEx, with consistent benefits across astigmatism severities. This data-driven, iterative refinement paradigm may standardize nomogram development and may be particularly valuable for less experienced surgeons transitioning from empirical adjustment to evidence-based, dynamically optimized surgical planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.