ArticleAmerican journal of cancer research2026
Circ_0075829 affects POU5F1B expression through sponging miR-576-3p to promote growth, invasion, and angiogenesis of colon cancer cells.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colon cancer represents a significant malignancy within the gastrointestinal tract, responsible for the annual loss of tens of thousands of lives globally. Circular RNA_0075829 (circ_0075829) is known to be dysregulated in various cancers and plays a role in cancer progression. However, its specific function in colon cancer remains largely unexplored. This study aimed to elucidate the function and underlying mechanisms of circ_0075829 in colon cancer through a series of in vitro assays, including cell counting kit-8, flow cytometry, transwell, tube formation, RNA pull-down, dual-luciferase reporter, and western blotting. Additionally, the role of circ_0075829 role in colon cancer was investigated in tumor-bearing mice using immunohistochemistry assays. The findings revealed that circ_0075829 was upregulated in colon cancer and was positively associated with adverse clinical features and poor prognosis in patients. Silencing circ_0075829 resulted in decreased colon cancer cell viability, tube formation, cell invasion, and expression levels of N-cadherin and vascular endothelial growth factor A (VEGFA), while promoting apoptosis and E-cadherin expression. Circ_0075829 acted as a molecular sponge for microRNA-576-3p (miR-576-3p), thereby upregulating the expression of POU class 5 homeobox 1B (POU5F1B) in colon cancer cells. The inhibitory effects of sh-circ_0075829 on the proliferation, invasion, and angiogenesis of colon cancer cells were negated upon miR-576-3p knockdown or POU5F1B overexpression.
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