ArticleFood science & nutrition2026
Oleanolic Acid Ameliorates Hepatic Lipid Metabolism and Autophagy in Type 2 Diabetic Mice via the STAT3 Signaling Pathway.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Exploring the Therapeutic Effects ofPharmaceuticals (Basel, Switzerland) · 2026Article
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8 authors.
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Abstract
Type 2 diabetes mellitus (T2DM) poses a major global health challenge due to its considerable disability and mortality rates. The complex etiology of T2DM involves hepatic steatosis and autophagy dysfunction. Previous research indicates that oleanolic acid (OA) ameliorates T2DM, with signal transducer and activator of transcription 3 (STAT3) serving as a crucial regulator in numerous cellular processes. Therefore, this study aims to explore whether the therapeutic effects of OA are associated with STAT3 activation and its potential role in hepatic lipid metabolism and autophagy in T2DM. T2DM was induced in mice by feeding a high-fat diet followed by multiple low-dose streptozotocin injections. OA notably lowered blood glucose and lipid levels, along with improvements in glucose tolerance and insulin sensitivity. Additionally, OA alleviated liver injury and steatosis. In T2DM mice, OA reduced hepatic protein and gene expression associated with fatty acid uptake/synthesis while enhancing those linked to fatty acid β-oxidation. Moreover, OA modulated autophagy-related proteins, as evidenced by increased p62 levels and decreased LC3-II and Beclin-1 levels. Molecular docking analysis predicted a potential interaction between OA and STAT3, and Western blot showed increased STAT3 phosphorylation at Y705 after OA treatment
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