ArticleJournal of the American Heart Association2026
Bilateral Adrenal Primary Aldosteronism Is Uniformly Present in Hypertensive Afro-Caribbean First-Generation Immigrants to Western Canada.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Race and Ancestry in Primary Aldosteronism.Journal of the American Heart Association · 2026Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncontrolled hypertension is prevalent in sub-Saharan Africa and a major contributor to premature morbidity. The reasons may not be identical to those reported in studies of Black patients in Western countries. Recent African immigration to western Canada permits the study of hypertension mechanisms in African Black patients.
methodsRetrospective study of 15 years' experience (2010-2025) with hypertensive first-generation African immigrants to a resistant hypertension clinic in Alberta, Canada.
resultsWith uniform screening for primary aldosteronism (PA), PA was found in 93% of all African patients (n=114) versus 46.8% in non-African referred patients (n=792;
conclusionsAmong first-generation African immigrants with hypertension, 93% fit a clear diagnosis of PA, a prevalence figure far in excess of any other population ever reported. Most of the PA phenotype was bilateral aldosterone excess; surgical cases and complete responders to adrenalectomy were rare. This, the largest detailed study of PA in African patients with hypertension, if confirmed, has important implications for hypertension assessment and treatment for African Black patients.
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