Observational studyJournal of gastroenterology and hepatology2026
Impact of Zinc-Dependent Enzymes on Zinc Deficiency and Inflammatory Response in Ulcerative Colitis.
Observational study in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Beyond Serum Zinc: Expanding the Understanding of Mucosal Zinc Homeostasis in Ulcerative Colitis.Journal of gastroenterology and hepatology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
aimZinc (Zn) deficiency occurs in 40% of patients with ulcerative colitis (UC). Although Zn-dependent enzymes are involved in intestinal immune regulation, their relationships with Zn deficiency and mucosal inflammation remain unclear. This study aimed to investigate the associations among Zn-dependent enzyme activities, serum Zn levels, and mucosal inflammatory cytokine mRNA expression in UC.
methodsPatients with UC who underwent colonoscopies from September 2019 to October 2020 were registered in a single-center prospective observational study. Serum Zn levels, serum and mucosal heat-resistant alkaline phosphatase (hrALP) activity, serum and mucosal ecto-5'-nucleotidase (NT5E)/CD73 activity, and mucosal inflammatory cytokine mRNA expression were evaluated.
resultsTwenty-nine patients with UC were enrolled. Serum Zn levels were lower in the nonclinical remission group and the non-endoscopic remission group. Tissue hrALP activity was higher and tissue NT5E/CD73 activity tended to be higher in Zn-deficient patients. Tissue hrALP was positively correlated with the Matts histological score, whereas tissue NT5E/CD73 activity showed a positive trend. Serum Zn levels were inversely correlated with tissue hrALP activity. Tissue hrALP and NT5E/CD73 activities were positively correlated with several mucosal inflammatory cytokines, whereas serum enzyme activities showed no significant correlations with inflammatory cytokine expression.
conclusionsIncreased mucosal Zn-dependent enzyme activities were associated with histological inflammation, Zn deficiency, and mucosal inflammatory cytokine expression in UC. These findings suggest that mucosal Zn-dependent enzyme activity may reflect local inflammatory status and altered Zn homeostasis in UC.
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