Evidence map›Paper›PMID 42464918›Full record

ArticlePediatric pulmonology2026

Effects of Combined Training on Cardiac Autonomic Modulation in Asthmatic Adolescents.

Nathália Ferreira Santos Couto, Bruno Rafael Vieira Souza Silva, Thiago de Novaes Ferreira, Anderson Gomes Pereira, Edil de Albuquerque Rodrigues Filho, Alexandre Sérgio Silva, Décio Medeiros, Emanuel Sávio Cavalcanti Sarinho, Breno Quintella Farah, Marco Aurélio de Valois Correia Júnior

Abstract read
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In one paragraph

Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nathália Ferreira Santos CoutoAssociated Postgraduate Program in Physical Education, Universidade de Pernambuco and Universidade Federal da Paraiba, Recife, Brazil.
Bruno Rafael Vieira Souza SilvaAssociated Postgraduate Program in Physical Education, Universidade de Pernambuco and Universidade Federal da Paraiba, Recife, Brazil.ORCID https://orcid.org/0000-0002-6140-6990
Thiago de Novaes FerreiraAssociated Postgraduate Program in Physical Education, Universidade de Pernambuco and Universidade Federal da Paraiba, Recife, Brazil.
Anderson Gomes PereiraDepartment of Physical Education, Universidade Federal de Pernambuco, Recife, Brazil.
Edil de Albuquerque Rodrigues FilhoDepartment of Physical Education, Universidade Federal de Pernambuco, Recife, Brazil.ORCID https://orcid.org/0000-0001-6203-3658
Alexandre Sérgio SilvaAssociated Postgraduate Program in Physical Education, Universidade de Pernambuco and Universidade Federal da Paraiba, Recife, Brazil.ORCID https://orcid.org/0000-0003-3576-9023
Décio MedeirosAllergy and Clinical Immunology Department, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil.ORCID https://orcid.org/0000-0003-1779-5762
Emanuel Sávio Cavalcanti SarinhoAllergy and Clinical Immunology Department, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil.ORCID https://orcid.org/0000-0003-3331-6274
Breno Quintella FarahDepartment of Physical Education, Universidade Federal Rural de Pernambuco, Recife, Brazil.ORCID https://orcid.org/0000-0003-2286-5892
Marco Aurélio de Valois Correia JúniorAssociated Postgraduate Program in Physical Education, Universidade de Pernambuco and Universidade Federal da Paraiba, Recife, Brazil.ORCID https://orcid.org/0000-0003-0386-5256

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) [Finance Code 001]
6 · The paper itself

Abstract

objectiveExercise-induced bronchoconstriction (EIB) is defined as the acute narrowing of the lower respiratory airways after exercise. This study aimed to verify the behavior of cardiac autonomic modulation after combined training in asthmatic adolescents with and without EIB.

methodsThis is a clinical study in which 16 asthmatic adolescents (10 with EIB and 6 without EIB) performed combined exercise (aerobic and resistance) for 12 weeks with a frequency of 3 sessions per week. The diagnosis of EIB was established based on a > 10% reduction in forced expiratory volume in 1 s (FEV

resultsThere was sympathetic impairment (mean RR interval and heart rate) in patients with and without EIB after the bronchoprovocation test in the 40 min evaluated, which improved after combined training at all times evaluated in patients without EIB and after 10 min in those with EIB (p < 0.001). The parasympathetic component (percentage of adjacent intervals over 50 ms[PNN50]) was not altered after the bronchoprovocation test in individuals without EIB before and after training. In individuals with EIB, pNN50 was changed 40 min after the bronchoprovocation test before training and showed improvement after 10 min (p < 0.001) in the reassessment.

conclusionAn improvement in autonomic response was observed in asthmatic adolescents without EIB following combined physical training, evident from the first minute post-bronchoprovocation test, whereas in those with EIB, this improvement became apparent after 10 min.

Indexed as

AsthmaAsthma, Exercise-InducedAutonomic Nervous SystemExercise TherapyHeartHeart RateResistance TrainingAdolescentExercise TestFemaleForced Expiratory VolumeHumansMaleadolescentsasthmaautonomic modulationexerciseexercise‐induced bronchospasmheart rate variability

Identifiers

PMID42464918
PMCPMC13377541

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.