ArticleCartilage2026
Effects of Compression on Extracellular Matrix Synthesis by Chondrocytes and Chondrosarcoma Cells.
Article in Cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveMechanical loading is critical for chondrocyte function and cartilage matrix production, yet its effects on clustered chondrocytes in end-stage osteoarthritis and on chondrosarcoma cells remain poorly understood. This study investigated how cyclic compression influences chondrocytes and chondrosarcoma cells cultured either as single cells or as micromasses.MethodsAn organ-on-chip platform was used to apply cyclic compression to chondrocytes and chondrosarcoma cells embedded in agarose as single cells or micromasses mimicking chondrocyte clusters. Deformation during loading was assessed, and after four days of stimulation, gene and protein expression of cartilage markers and extracellular matrix components were analyzed.ResultsChondrocyte micromasses deformed less than single cells and showed behavior resembling chondrosarcoma cells and their micromasses. All four culture models exhibited distinct mechanobiological responses after four days of compression. Mechanical loading promoted collagen I reorganization in micromasses and increased
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