Evidence map›Paper›PMID 42464766›Full record

ArticleDevelopment (Cambridge, England)2026

Fibroblast response to burn injury in larval zebrafish mirrors developmental maturation and is inhibited by infiltrating neutrophils.

Adam Horn, Yiran Hou, Jayne M Squirrell, Alexandra M Fister, Julie Rindy, Veronika Miskolci, Jonathan H Schrope, Russell Burke, Colin Dewey, Kevin W Eliceiri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adam HornDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53705, USA.
Yiran HouDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53705, USA.
Jayne M SquirrellCenter for Quantitative Cell Imaging, University of Wisconsin - Madison, Madison, WI 53705, USA.
Alexandra M FisterDepartment of Cell and Regenerative Biology, University of Wisconsin - Madison, Madison, WI 53705, USA.ORCID 0000-0001-9472-1455
Julie RindyDepartment of Pediatrics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Veronika MiskolciDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53705, USA.ORCID 0000-0001-7900-4626
Jonathan H SchropeDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53705, USA.
Russell BurkeDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53705, USA.ORCID 0009-0000-7799-3715
Colin DeweyDepartment of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Kevin W EliceiriCenter for Quantitative Cell Imaging, University of Wisconsin - Madison, Madison, WI 53705, USA.
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53705, USA.ORCID 0000-0001-7940-6254

Funding

Cell migration and wound repairR35GM118027 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2016 to 2026
$7.5M
Metabolic regulation of macrophage-dependent wound healing in vivoK99GM138699 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MISKOLCI, VERONIKA · 2021 to 2022
$200k
NIGMS NIH HHS K99 GM138699NIGMS NIH HHS R35 GM118027NIGMS NIH HHS R35GM118027-05R35GM118027-05
6 · The paper itself

Abstract

Fibroblasts mediate tissue repair after damage, but aberrant fibroblast behavior in response to injury can result in impaired wound healing. Severe burn injury often results in tissue scarring, but the underlying mechanisms by which fibroblasts respond to burn injury and the role of inflammation in fibrosis are not well understood. Here, we have developed fluorescent reporters of collagen-expressing mesenchymal cells, enabling real-time imaging of fibroblasts during homeostatic development and in response to burn injury using larval zebrafish. We find that fibroblasts derived from the mesenchyme respond to burn injury by engaging in a maturation process, characterized by the expression of vimentin, which is reminiscent of larval development. In burned tissue, fibroblast maturation is perturbed by prolonged neutrophil infiltration, resulting in disorganized extracellular matrix (ECM) and delayed ECM remodeling, which can be rescued by neutrophil depletion. This work adds to our understanding of fibroblast development in zebrafish and shows that collagen-expressing mesenchymal cells regulate ECM remodeling in coordination with immune cells during burn wound healing.

Indexed as

BurnsFibroblastsNeutrophil InfiltrationNeutrophilsZebrafishAnimalsCollagenExtracellular MatrixLarvaMesodermVimentinWound HealingCollagenVimentinBurnECM remodelingFibroblast

Identifiers

PMID42464766
PMCPMC13552621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.