Evidence map›Paper›PMID 42464709›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Skeletal Reorganization of Cycloalkylamines Into Angular Azatetracyclic Scaffolds.

Yun-Peng Wang, Wujiong Xia, Bao-Kuan Guo, Kun Fang, Tong-Mei Ding, Shu-Yu Zhang, Si-Hua Hou, Yong-Qiang Tu

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yun-Peng WangSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.
Wujiong XiaState Key Lab of Urban Water Resource and Environment, Harbin Institute of Technology (Shenzhen), Shenzhen, China.ORCID https://orcid.org/0000-0001-9396-9520
Bao-Kuan GuoSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.
Kun FangSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.
Tong-Mei DingSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-2546-961X
Shu-Yu ZhangSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-1811-4159
Si-Hua HouSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-7397-8753
Yong-Qiang TuSchool of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-9784-4052

Funding

National Key R&D Program of China 2023YFA1506400National Key R&D Program of China 2023YFA1506401National Key R&D Program of China 2023YFA1506403NSFC 22471160NSFC 92256303NSFC and 22531005Postdoctoral Fellowship Program of CPSF BX20240218Postdoctoral Fellowship Program of CPSF GZC20241025Shanghai Frontiers Science Center of Drug Target Identification and Delivery ZXWH2170101State Key Laboratory of Synergistic Chem-Bio Synthesis sklscbs202543
6 · The paper itself

Abstract

The efficient, single-step construction of angular azatetracyclic frameworks bearing vicinal quaternary stereocenters remains a formidable challenge in synthetic chemistry. Herein, we disclose the first borane-catalyzed cascade reorganization of N-cycloalkylidenyl (CAD)-substituted aryl cycloalkylamines that enables rapid access to these architectures. Initiated by B(C

Indexed as

angular azatetracyclic scaffoldscyclization/dicycloexpansionskeletal reorganizationvicinal quaternary carbon centers

Identifiers

PMID42464709
PMCPMC13528515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.