Evidence map›Paper›PMID 42464642›Full record

ArticleInternational journal of oncology2026

YAP1‑mediated cytoplasmic‑nuclear translocation of SREBP2 promotes colorectal cancer via regulation of cholesterol metabolism.

Luhui Zhong, Min Sun, Di Wu, Yulan Zeng, Min Zhou, Rui Gong, Feifei Gu, Kai Zhang, Xiaoyan Hu, Yue Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luhui Zhong *Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Min Sun *Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Di Wu *Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Yulan Zeng *Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Min ZhouDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Rui GongHealth Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Feifei GuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Kai ZhangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Xiaoyan HuDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
Yue HuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) cells reprogram multiple metabolic pathways, including anaerobic glycolysis, lipogenesis and amino acid metabolism, to support their rapid cell division. However, the key regulators driving these metabolic alterations in CRC remain unknown. In the present study, immunohistochemistry staining of a tissue microarray demonstrated that yes‑associated protein 1 (YAP1) was markedly upregulated in CRC tissues and strongly associated with worse patient survival. Knocking down YAP1 inhibited the proliferation and cholesterol accumulation of CRC cells both

Indexed as

Adaptor Proteins, Signal TransducingCholesterolColorectal NeoplasmsSterol Regulatory Element Binding Protein 2Transcription FactorsAnimalsCell Line, TumorCell NucleusCell ProliferationCytoplasmFemaleGene Expression Regulation, NeoplasticHumansMaleMetabolic ReprogrammingMiceAdaptor Proteins, Signal TransducingCholesterolSREBF2 protein, humanSterol Regulatory Element Binding Protein 2Transcription FactorsYAP1 protein, humanYAP-Signaling Proteinscholesterol metabolismcolorectal cancercytoplasmic‑nuclear translocationsterol regulatory element binding protein 2yes‑­associated protein 1

Identifiers

PMID42464642
PMCPMC13387130

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.