Evidence map›Paper›PMID 42464549›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Effects of high-concentration of vancomycin and meropenem on viability and osteogenic differentiation of rat bone marrow mesenchymal stem cells].

Junjie Hu, Fei Wang, Yichang Li, Yicheng Li, Guangzhao Zhu, Xingbu Meng, Bo Liu, Li Cao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junjie HuDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Fei WangDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Yichang LiDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Yicheng LiDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Guangzhao ZhuDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Xingbu MengDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Bo LiuDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Li CaoDepartment of Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effects of high-concentration of vancomycin and meropenem on the viability and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs), and to provide experimental evidence for local antibiotic treatment of periprosthetic joint infection (PJI). Methods: Rat BMSCs were cultured with vancomycin and meropenem at different concentrations (10-10 000 μg/mL). A cell counting kit 8 assay was used to assess the effects of the antibiotics on cell viability. The antibiotic concentration at which cell viability began to decrease by more than 50% compared to the control group (cells cultured without antibiotics) after 7 days was selected as the upper concentration limit for subsequent experiments. The lowest concentration at which cell viability significantly decreased compared to the control group after 7 days ( Results: The inhibitory effects of vancomycin and meropenem on BMSCs viability gradually increased with prolonged intervention. After 7 days, the threshold concentration for a significant decrease in BMSCs viability was 500 μg/mL for both antibiotics ( Conclusion: High-concentration (3 000 μg/mL) of vancomycin and meropenem administered for more than 7 days may inhibit the viability and osteogenic differentiation of rat BMSCs.

Indexed as

Anti-Bacterial AgentsBone Marrow CellsCell DifferentiationMesenchymal Stem CellsOsteogenesisThienamycinsVancomycinAnimalsApoptosisCells, CulturedCell SurvivalCore Binding Factor Alpha 1 SubunitDose-Response Relationship, DrugMaleMeropenemOsteopontinAnti-Bacterial AgentsCore Binding Factor Alpha 1 SubunitMeropenemOsteopontinRunx2 protein, ratSp7 protein, ratSpp1 protein, ratThienamycinsTranscription FactorsVancomycinbone marrow mesenchymal stem cellsmeropenemosteogenic differentiationPeriprosthetic joint infectionratvancomycin

Identifiers

PMID42464549
PMCPMC13391825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.