Exploring Biofilm Inhibition Potential of Imidazo-Pyridine Linked Tetrazoles Against Candida albicans: Synthesis, Biological Evaluation With Computational Studies.

Madalambika, A C Kumar, P M BharathKumar, K B Vilas Gowda, Ramith Ramu, Nagaraja Naik

Abstract read

In one paragraph

Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

MadalambikaDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, Karnataka, India.

A C KumarDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, Karnataka, India.ORCID https://orcid.org/0000-0002-4824-1976

P M BharathKumarDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, Karnataka, India.ORCID https://orcid.org/0009-0003-9378-5213

K B Vilas GowdaDepartment of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

Ramith RamuDepartment of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.ORCID https://orcid.org/0000-0003-2776-5815

Nagaraja NaikDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, Karnataka, India.ORCID https://orcid.org/0000-0002-9303-1193

Funding

Karnataka Science and Technology Promotion Society (KSTePS), DST Ph.D. Fellowship Programme. DST/KSTePS/Ph.D.Fellowship/CHE-06:2022-23/989

6 · The paper itself

Abstract

Infectious diseases remain one of the major global health challenges due to their rapid transmission and evolving pathogenic mechanisms. Among them, Candida albicans has emerged as a significant opportunistic antifungal pathogen, which is responsible for biofilm-associated infections. In the present study, a library of new tetrazole bearing imidazo-pyridine molecules (4a-4j) was synthesised and characterised through spectroscopic techniques (

Indexed as

Antifungal AgentsBiofilmsCandida albicansImidazolesPyridinesTetrazolesHEK293 CellsHemolysisHumansMicrobial Sensitivity TestsMolecular Docking SimulationAntifungal AgentsImidazolesPyridinesTetrazolesbiofilm inhibitionCandida albicanscytotoxicityhemolytic assayimidazo‐pyridinein silico studiestetrazole

Identifiers

PMID42464506

DOI10.1111/cbdd.70359

PMCPMC13376436

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.