Evidence map›Paper›PMID 42464405›Full record

ArticleBiology direct2026

ANKRD49 promotes immune evasion in lung adenocarcinoma by activating the MEF2A/PD‑L1 axis.

Tian-Qi Sun, Shuo Wu, Jing Qiao, Gang Liang, Chao-Feng Liu, Hui-Yu Jiang, Kai-Yuan Liu, Hai-Long Wang, Min Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tian-Qi Sun *Department of Pulmonary and Critical Care Medicine, the First Hospital, Shanxi Medical University; Shanxi Key Laboratory of Chronic Respiratory Diseases and Pneumoconiosis, NHC Key Laboratory of Pneumoconiosis, Taiyuan, 030001, China.
Shuo Wu *School of Basic Medicine, Basic Medical Science Center, Shanxi Medical University, No.55 Wenhua Street, Jinzhong, 030600, Shanxi, China.
Jing Qiao *Department of Pulmonary and Critical Care Medicine, the First Hospital, Shanxi Medical University; Shanxi Key Laboratory of Chronic Respiratory Diseases and Pneumoconiosis, NHC Key Laboratory of Pneumoconiosis, Taiyuan, 030001, China.
Gang Liang *Department of Pathology, the First Hospital, Shanxi Medical University, Taiyuan, 030001, China.
Chao-Feng LiuDepartment of Pulmonary and Critical Care Medicine, the First Hospital, Shanxi Medical University; Shanxi Key Laboratory of Chronic Respiratory Diseases and Pneumoconiosis, NHC Key Laboratory of Pneumoconiosis, Taiyuan, 030001, China.
Hui-Yu JiangDepartment of Pulmonary and Critical Care Medicine, the First Hospital, Shanxi Medical University; Shanxi Key Laboratory of Chronic Respiratory Diseases and Pneumoconiosis, NHC Key Laboratory of Pneumoconiosis, Taiyuan, 030001, China.
Kai-Yuan LiuShanxi Chiming Biotechnology Co., Ltd., Taiyuan, 030002, China.
Hai-Long WangSchool of Basic Medicine, Basic Medical Science Center, Shanxi Medical University, No.55 Wenhua Street, Jinzhong, 030600, Shanxi, China. longwty@sxmu.edu.cn.
Min PangDepartment of Pulmonary and Critical Care Medicine, the First Hospital, Shanxi Medical University; Shanxi Key Laboratory of Chronic Respiratory Diseases and Pneumoconiosis, NHC Key Laboratory of Pneumoconiosis, Taiyuan, 030001, China. pangminsdyy@sxmu.edu.cn.

Funding

the Central Guidance Fund for Local Science and Technology Development Projects YDZJSX2024D062
6 · The paper itself

Abstract

Non‑small cell lung cancer (NSCLC), particularly lung adenocarcinoma (LUAD), exhibits a high rate of primary resistance to immune checkpoint inhibitors, underscoring the need to decipher the molecular mechanisms of immune evasion. Here, we identify ANKRD49 as a critical regulator of PD‑L1 expression and immunosuppression in LUAD. Immunohistochemical analysis of clinical LUAD specimens revealed that high ANKRD49 expression correlates with reduced CD4

Indexed as

Adenocarcinoma of LungB7-H1 AntigenImmune EvasionLung NeoplasmsMEF2 Transcription FactorsMuscle ProteinsAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceNuclear ProteinsRepressor ProteinsANKRD1 protein, humanB7-H1 AntigenCD274 protein, humanMEF2A protein, humanMEF2 Transcription FactorsMuscle ProteinsNuclear ProteinsRepressor ProteinsANKRD49Ankyrin repeat domainImmune evasionLung adenocarcinomaMEF2APD-L1

Identifiers

PMID42464405
PMCPMC13576347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.