Evidence map›Paper›PMID 42464371›Full record

ArticleCardio-oncology (London, England)2026

The risk of myocardial infarction and ischemic stroke in pelvic cancer surgery.

Nicola Giudici, Johan Björklund, Renata Zelic, Per Henrik Vincent, Simone Scuderi, Peter Wiklund, Markus Aly, Olof Akre, Juhana Rautiola

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Article in Cardio-oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Nicola GiudiciDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. nicolagiudici@gmail.com.ORCID http://orcid.org/0009-0005-9844-1799
Johan BjörklundDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Renata ZelicDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Per Henrik VincentDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Simone ScuderiDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Peter WiklundDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Markus AlyDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Olof AkreDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Juhana RautiolaDepartment of Molecular Medicine and Surgery, Department of Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial infarction and ischemic stroke are common causes of morbidity after major cancer surgery. Understanding the risks associated with both open and laparoscopic surgery is crucial in reducing postoperative morbidity and mortality.

methodsThis nationwide cohort study included patients who underwent major cancer surgery in the pelvis from 2000 to 2015. The primary outcome was the incidence of myocardial infarction and ischemic stroke within 90 days postoperatively. Adjusted odds ratios (OR) were estimated using logistic regression adjusted for propensity score and risks by regression standardization.

resultsA total of 22,619 patients operated with laparoscopic and 70,896 patients operated with open approach were included in the analysis. The crude 90-day cumulative risks of myocardial infarction and ischemic stroke were 0.66% and 0.48%, respectively. Laparoscopic surgery was associated with lower odds of myocardial infarction within 30 days (OR 0.39, 95% CI 0.23-0.62) and 90 days (OR 0.57, 95% CI 0.41-0.81) compared to open surgery. Similarly, an association was observed for ischemic stroke (OR 0.67, 95% CI 0.38-1.05 at 30 days; OR 0.69, 95% CI 0.45-0.80 at 90 days).

conclusionsLaparoscopic surgery is associated with reduced postoperative risk of myocardial infarction and ischemic stroke compared to open surgery in the treatment of pelvic cancers. These findings favor the broader adoption of minimally invasive techniques in clinical practice.

Indexed as

Ischemic strokeLaparoscopic surgeryMinimally invasive surgeryMyocardial infarctionOpen surgeryPelvic cancerPostoperative complications

Identifiers

PMID42464371
PMCPMC13656610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.