Evidence map›Paper›PMID 42464351›Full record

Observational studyArthritis research & therapy2026

Defining and validating a high specificity MRI cut-off for the radiographic part of the modified New York criteria in patients with axial spondyloarthritis.

Anna Ef Hadsbjerg, Simon Krabbe, Nora Vladimirova, Adrian Ciurea, Kristýna Bubová, Monika Gregová, Michael J Nissen, Burkhard Möller, Raphael Micheroli, Susanne J Pedersen and 21 more

Abstract readMulticenter StudyObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Arthritis research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

31 authors.

Anna Ef HadsbjergCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark. anna.enevold.floeistrup.hadsbjerg@regionh.dk.ORCID http://orcid.org/0000-0001-8196-4327
Simon KrabbeCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Nora VladimirovaCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Adrian CiureaDepartment of Rheumatology, University Hospital of Zurich, University of Zurich, Rämistrasse 100, Zurich, Zurich, 8091, Switzerland.
Kristýna BubováInstitute of Rheumatology, Department of Rheumatology, First Faculty of Medicine, Charles University, Kateřinská 1660/32, Prague, Prague 2, 121 08, Czech Republic.
Monika GregováInstitute of Rheumatology, Department of Rheumatology, First Faculty of Medicine, Charles University, Kateřinská 1660/32, Prague, Prague 2, 121 08, Czech Republic.
Michael J NissenRheumatology Department, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, Geneva, Geneva, 1211, Switzerland.
Burkhard MöllerDepartment of Rheumatology and Immunology, Inselspital, University Hospital Bern, Freiburgstrasse 20, Bern, Bern, 3010, Switzerland.
Raphael MicheroliDepartment of Rheumatology, University Hospital of Zurich, University of Zurich, Rämistrasse 100, Zurich, Zurich, 8091, Switzerland.
Susanne J PedersenCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Jakub ZávadaInstitute of Rheumatology, Department of Rheumatology, First Faculty of Medicine, Charles University, Kateřinská 1660/32, Prague, Prague 2, 121 08, Czech Republic.
Ziga SnojInstitute of Radiology, UMC Ljubljana, Zaloška cesta 7, Ljubljana, Ljubljana, 1000, Slovenia.
Karlo PintaricInstitute of Radiology, UMC Ljubljana, Zaloška cesta 7, Ljubljana, Ljubljana, 1000, Slovenia.
Bjorn GudbjornssonCentre for Rheumatology Research, Faculty of Medicine, Landspitali University Hospital, University of Iceland, Eiríksgata 5, Reykjavik, Reykjavik, 101, Iceland.
Ziga RotarDepartment of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, Ljubljana, Ljubljana, 1000, Slovenia.
Iris EshedDepartment of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer affiliated with School of Medicine, Tel Aviv University, 2 Sheba Rd, Tel Aviv, Ramat-Gan, 52621, Israel.
Iwona Sudol-SzopinskaDepartment of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, Warsaw, Warsaw, 02-637, Poland.
Kasper GosvigDepartment of Radiology, Copenhagen University Hospital Herlev- Gentofte, Borgmester Ib Juuls Vej 1, Herlev, Herlev, 2730, Denmark.
Torsten DiekhoffDepartment of Radiology, Brandenburg Medical School, Immanuel Clinic Ruedersdorf, Am Rosengarten 3, Ruedersdorf bei Berlin, 15562, Germany.
Robert Gw LambertDepartment of Radiology and Diagnostic Imaging, University of Alberta, 8440 112 St NW, Edmonton, Edmonton, T6G 2B7, AB, Canada.
Manouk de HoogeDepartment of Rheumatology, Gent University Hospital, Ghent University, Corneel Heymanslaan 10, Ghent, Gent, 9000, Belgium.
Jakob M MøllerDepartment of Radiology, Copenhagen University Hospital Herlev- Gentofte, Borgmester Ib Juuls Vej 1, Herlev, Herlev, 2730, Denmark.
Karel GoricanDepartment of Radiology, University of Montreal Health Center, 2000 René-Lévesque Blvd East, Montreal, Montreal, QC, QC, H3A 1A5, Canada.
Marie WetterslevCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Stephanie WichukDivision of Rheumatology, University of Alberta, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada.
Maurice DonzallazDepartment of Rheumatology, University Hospital of Zurich, University of Zurich, Rämistrasse 100, Zurich, Zurich, 8091, Switzerland.
Alexander BernatschekDepartment of Rheumatology, University Hospital of Zurich, University of Zurich, Rämistrasse 100, Zurich, Zurich, 8091, Switzerland.
Stylianos GeorgiadisCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Merete Lund HetlandCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Lykke M ØrnbjergCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.
Mikkel ØstergaardCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Valdemar Hansens Vej 17, entrance 5, Righospitalet, Glostrup, Glostrup, 2600, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to the modified New York criteria (mNYc), moderate-severe sacroiliac joint (SIJ) structural damage on radiography is necessary for classifying radiographic axial spondyloarthritis (r-axSpA). In contrast to radiography, MRI provides no ionizing radiation, higher sensitivity for structural damage, better inter-reader reliability, and is gradually replacing radiography. Therefore, we aimed to develop and validate a high specificity MRI cut-off to the radiographic component of the mNYc (rad-mNYc), defined as MRI findings that correspond to an mNY-positive radiograph.

methodsPatients diagnosed with axSpA with available SIJ MRI and radiograph from five European clinical registries in the EuroSpA Collaboration were included. MRIs were read according to the SPARCC structural score (based on 5 predefined or all slices) and radiographs the rad-mNYc. Cut-offs with 95% specificity for rad-mNYc-positivity for MRI sum scores for individual lesions and for an MRI SIJ hierarchical Composite Structural Damage Score (CSDS

resultsOverall, 640 patients were included; 296 (46%) were rad-mNYc positive. The 95%-specificity cut-off was ≥ 30 for the composite score CSDS

conclusionsA composite MRI-score based on assessing erosion, backfill and ankylosis for five predefined semicoronal SIJ slices (CSDS

Indexed as

Axial SpondyloarthritisMagnetic Resonance ImagingSacroiliac JointAdultFemaleHumansMaleMiddle AgedRadiographyRegistriesReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexAnkylosing spondylitisClassification criteriaMagnetic resonance imagingRadiographySpondyloarthritis

Identifiers

PMID42464351
PMCPMC13656707

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