Evidence map›Paper›PMID 42464331›Full record

ArticleBiology direct2026

Contributions of dorsal medial prefrontal cortex GABAergic mu opioid receptors on acute restraint stress-induced anxiety-like behavior.

Yinan Du, Fenghua Xu, Junmin Zhang, Yukui Zhao, Shuyi Liu, Yuan Chang, Yiwei Liu, Yingchun Yang, Yingying Li, Hongyu Qin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yinan Du *Diagnosis and Treatment Center for Neurological Diseases, The first Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China.
Fenghua Xu *MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Junmin Zhang *MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Yukui ZhaoMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Shuyi LiuMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Yuan ChangMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Yiwei LiuDiagnosis and Treatment Center for Neurological Diseases, The first Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China.
Yingchun YangDiagnosis and Treatment Center for Neurological Diseases, The first Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China.
Yingying LiCentral Laboratory, The first Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710061, China.
Hongyu QinCentral Laboratory, The first Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710061, China.
Chunling WeiMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Qiaohua ZhengMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Yanning QiaoMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Yihui LiuMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Wei RenMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Jing HanMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Aozhuo ZhangMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Zhiqiang LiuMOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
Fei GaoDiagnosis and Treatment Center for Neurological Diseases, The first Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China. gaofei@xiyi.edu.cn.

Funding

Excellent Graduate Training Program of Shaanxi Normal University LHRCYB223009National Natural Science Foundation of China 82071516National Natural Science Foundation of China 91949105Natural Science Basic Research Plan in Shaanxi Province of China 2024JC-YBQN-0902Scientific Research Foundation of Xi'an Medical University XYFYQDJF-2025-02
6 · The paper itself

Abstract

The body's defensive emotional reaction to stress presents as anxiety. Nevertheless, long-term anxious stimuli can cause pathological anxiety disorders together with endocrine system, neural system, and immune system dysfunctions. Thus, researchers should understand the neural processes that govern anxiety during stress to create preventive and care plans. By combining behavioral tests, chemogenetic strategies, c-fos stainings, and whole-cell patch clamp recordings, this study looked into the function of dorsal medial prefrontal cortex (dmPFC) mu opioid receptors (MORs), specifically GABAergic MORs (MOR

Indexed as

AnxietyGABAergic NeuronsPrefrontal CortexReceptors, Opioid, muStress, PsychologicalAnimalsBehavior, AnimalMaleMiceMice, Inbred C57BLRestraint, PhysicalReceptors, Opioid, muAcute restraint stressAnxietyDorsal medial prefrontal cortexMu opioid receptors

Identifiers

PMID42464331
PMCPMC13656358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.